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Impact of nonrandom selection mechanisms on the causal effect estimation for two-sample Mendelian randomization methods
Nonrandom selection in one-sample Mendelian Randomization (MR) results in biased estimates and inflated type I error rates only when the selection effects are sufficiently large. In two-sample MR, the different selection mechanisms in two samples may more seriously affect the causal effect estimatio...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8963545/ https://www.ncbi.nlm.nih.gov/pubmed/35298462 http://dx.doi.org/10.1371/journal.pgen.1010107 |