The relationship between body mass index and neurologic outcomes in survivors of out-of-hospital cardiac arrest treated with targeted temperature management

BACKGROUND: The association of body mass index with outcome in patients treated with targeted temperature management (TTM) after out-of-hospital cardiac arrest (OHCA) is unclear. The purpose of this study was to examine the effect of body mass index (BMI) on neurological outcomes and mortality in re...

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Autores principales: Bang, Hyo Jin, Park, Kyu Nam, Youn, Chun Song, Kim, Han Joon, Oh, Sang Hoon, Lim, Jee Yong, Song, Hwan, Kim, Soo Hyun, Jeong, Won Jung, Kim, Hyo Joon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8963585/
https://www.ncbi.nlm.nih.gov/pubmed/35349593
http://dx.doi.org/10.1371/journal.pone.0265656
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author Bang, Hyo Jin
Park, Kyu Nam
Youn, Chun Song
Kim, Han Joon
Oh, Sang Hoon
Lim, Jee Yong
Song, Hwan
Kim, Soo Hyun
Jeong, Won Jung
Kim, Hyo Joon
author_facet Bang, Hyo Jin
Park, Kyu Nam
Youn, Chun Song
Kim, Han Joon
Oh, Sang Hoon
Lim, Jee Yong
Song, Hwan
Kim, Soo Hyun
Jeong, Won Jung
Kim, Hyo Joon
author_sort Bang, Hyo Jin
collection PubMed
description BACKGROUND: The association of body mass index with outcome in patients treated with targeted temperature management (TTM) after out-of-hospital cardiac arrest (OHCA) is unclear. The purpose of this study was to examine the effect of body mass index (BMI) on neurological outcomes and mortality in resuscitated patients treated with TTM after OHCA. METHODS: This multicenter, prospective, observational study was performed with data from 22 hospitals included in the Korean Hypothermia Network KORHN-PRO registry. Comatose adult patients treated with TTM after OHCA between October 2015 and December 2018 were enrolled. The BMI of each patient was calculated and classified according to the criteria of the World Health Organization (WHO). Each group was analyzed in terms of demographic characteristics and associations with six-month neurologic outcomes and mortality after cardiac arrest (CA). RESULTS: Of 1,373 patients treated with TTM identified in the registry, 1,315 were included in this study. One hundred two patients were underweight (BMI <18.5 kg/m(2)), 798 were normal weight (BMI 18.5–24.9 kg/m(2)), 332 were overweight (BMI 25–29.9 kg/m(2)), and 73 were obese (BMI ≥ 30 kg/m(2)). The higher BMI group had younger patients and a greater incidence of diabetes and hypertension. Six-month neurologic outcomes and mortality were not different among the BMI groups (p = 0.111, p = 0.234). Univariate and multivariate analyses showed that BMI classification was not associated with six-month neurologic outcomes or mortality. In the subgroup analysis, the underweight group treated with TTM at 33°C was associated with poor neurologic outcomes six months after CA (OR 2.090, 95% CI 1.010–4.325, p = 0.047), whereas the TTM at 36°C group was not (OR 0.88, 95% CI 0.249–3.112, p = 0.843). CONCLUSIONS: BMI was not associated with six-month neurologic outcomes or mortality in patients surviving OHCA. However, in the subgroup analysis, underweight patients were associated with poor neurologic outcomes when treated with TTM at 33°C.
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spelling pubmed-89635852022-03-30 The relationship between body mass index and neurologic outcomes in survivors of out-of-hospital cardiac arrest treated with targeted temperature management Bang, Hyo Jin Park, Kyu Nam Youn, Chun Song Kim, Han Joon Oh, Sang Hoon Lim, Jee Yong Song, Hwan Kim, Soo Hyun Jeong, Won Jung Kim, Hyo Joon PLoS One Research Article BACKGROUND: The association of body mass index with outcome in patients treated with targeted temperature management (TTM) after out-of-hospital cardiac arrest (OHCA) is unclear. The purpose of this study was to examine the effect of body mass index (BMI) on neurological outcomes and mortality in resuscitated patients treated with TTM after OHCA. METHODS: This multicenter, prospective, observational study was performed with data from 22 hospitals included in the Korean Hypothermia Network KORHN-PRO registry. Comatose adult patients treated with TTM after OHCA between October 2015 and December 2018 were enrolled. The BMI of each patient was calculated and classified according to the criteria of the World Health Organization (WHO). Each group was analyzed in terms of demographic characteristics and associations with six-month neurologic outcomes and mortality after cardiac arrest (CA). RESULTS: Of 1,373 patients treated with TTM identified in the registry, 1,315 were included in this study. One hundred two patients were underweight (BMI <18.5 kg/m(2)), 798 were normal weight (BMI 18.5–24.9 kg/m(2)), 332 were overweight (BMI 25–29.9 kg/m(2)), and 73 were obese (BMI ≥ 30 kg/m(2)). The higher BMI group had younger patients and a greater incidence of diabetes and hypertension. Six-month neurologic outcomes and mortality were not different among the BMI groups (p = 0.111, p = 0.234). Univariate and multivariate analyses showed that BMI classification was not associated with six-month neurologic outcomes or mortality. In the subgroup analysis, the underweight group treated with TTM at 33°C was associated with poor neurologic outcomes six months after CA (OR 2.090, 95% CI 1.010–4.325, p = 0.047), whereas the TTM at 36°C group was not (OR 0.88, 95% CI 0.249–3.112, p = 0.843). CONCLUSIONS: BMI was not associated with six-month neurologic outcomes or mortality in patients surviving OHCA. However, in the subgroup analysis, underweight patients were associated with poor neurologic outcomes when treated with TTM at 33°C. Public Library of Science 2022-03-29 /pmc/articles/PMC8963585/ /pubmed/35349593 http://dx.doi.org/10.1371/journal.pone.0265656 Text en © 2022 Bang et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Bang, Hyo Jin
Park, Kyu Nam
Youn, Chun Song
Kim, Han Joon
Oh, Sang Hoon
Lim, Jee Yong
Song, Hwan
Kim, Soo Hyun
Jeong, Won Jung
Kim, Hyo Joon
The relationship between body mass index and neurologic outcomes in survivors of out-of-hospital cardiac arrest treated with targeted temperature management
title The relationship between body mass index and neurologic outcomes in survivors of out-of-hospital cardiac arrest treated with targeted temperature management
title_full The relationship between body mass index and neurologic outcomes in survivors of out-of-hospital cardiac arrest treated with targeted temperature management
title_fullStr The relationship between body mass index and neurologic outcomes in survivors of out-of-hospital cardiac arrest treated with targeted temperature management
title_full_unstemmed The relationship between body mass index and neurologic outcomes in survivors of out-of-hospital cardiac arrest treated with targeted temperature management
title_short The relationship between body mass index and neurologic outcomes in survivors of out-of-hospital cardiac arrest treated with targeted temperature management
title_sort relationship between body mass index and neurologic outcomes in survivors of out-of-hospital cardiac arrest treated with targeted temperature management
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8963585/
https://www.ncbi.nlm.nih.gov/pubmed/35349593
http://dx.doi.org/10.1371/journal.pone.0265656
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