A CNN model for predicting binding affinity changes between SARS-CoV-2 spike RBD variants and ACE2 homologues

The cellular entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) involves the association of its receptor binding domain (RBD) with human angiotensin converting enzyme 2 (hACE2) as the first crucial step. Efficient and reliable prediction of RBD-hACE2 binding affinity changes upon...

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Detalles Bibliográficos
Autores principales: Chen, Chen, Boorla, Veda Sheersh, Chowdhury, Ratul, Nissly, Ruth H., Gontu, Abhinay, Chothe, Shubhada K., LaBella, Lindsey, Jakka, Padmaja, Ramasamy, Santhamani, Vandegrift, Kurt J., Nair, Meera Surendran, Kuchipudi, Suresh V., Maranas, Costas D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8963690/
https://www.ncbi.nlm.nih.gov/pubmed/35350198
http://dx.doi.org/10.1101/2022.03.22.485413

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8963690/
https://www.ncbi.nlm.nih.gov/pubmed/35350198
http://dx.doi.org/10.1101/2022.03.22.485413

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