Cargando…

Effects of Receptor Specificity and Conformational Stability of Influenza A Virus Hemagglutinin on Infection and Activation of Different Cell Types in Human PBMCs

Humans can be infected by zoonotic avian, pandemic and seasonal influenza A viruses (IAVs), which differ by receptor specificity and conformational stability of their envelope glycoprotein hemagglutinin (HA). It was shown that receptor specificity of the HA determines the tropism of IAVs to human ai...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dorna, Jens, Kaufmann, Andreas, Bockmann, Viktoria, Raifer, Hartmann, West, Johanna, Matrosovich, Mikhail, Bauer, Stefan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8963867/ https://www.ncbi.nlm.nih.gov/pubmed/35359920 http://dx.doi.org/10.3389/fimmu.2022.827760

Ejemplares similares

Characterization of changes in the hemagglutinin that accompanied the emergence of H3N2/1968 pandemic influenza viruses
por: West, Johanna, et al.
Publicado: (2021)

Altering the Immunogenicity of Hemagglutinin Immunogens by Hyperglycosylation and Disulfide Stabilization
por: Thornlow, Dana N., et al.
Publicado: (2021)

Analysis of the conserved protective epitopes of hemagglutinin on influenza A viruses
por: Jiao, Chenchen, et al.
Publicado: (2023)

RNA-Cholesterol Nanoparticles Function as Potent Immune Activators via TLR7 and TLR8
por: Obermann, Hannah-Lena, et al.
Publicado: (2022)

Divalent cation-induced conformational changes of influenza virus hemagglutinin
por: Seok, Jong Hyeon, et al.
Publicado: (2020)

A Potent Anti-influenza Compound Blocks Fusion through Stabilization of the Prefusion Conformation of the Hemagglutinin Protein
por: White, Kris M., et al.
Publicado: (2014)

Enhanced Immunogenicity of Stabilized Trimeric Soluble Influenza Hemagglutinin
por: Weldon, William C., et al.
Publicado: (2010)

Protective Efficacy of an Orf Virus-Vector Encoding the Hemagglutinin and the Nucleoprotein of Influenza A Virus in Swine
por: Joshi, Lok R., et al.
Publicado: (2021)

Comparative Immunogenicity of Bacterially Expressed Soluble Trimers and Nanoparticle Displayed Influenza Hemagglutinin Stem Immunogens
por: Kar, Uddipan, et al.
Publicado: (2022)

Harnessing an RNA-mediated chaperone for the assembly of influenza hemagglutinin in an immunologically relevant conformation
por: Yang, Seung Won, et al.
Publicado: (2018)

Conformational modulation of influenza virus hemagglutinin: characterization and in vivo efficacy of monomeric form
por: Seok, Jong Hyeon, et al.
Publicado: (2017)

Molecular Mechanisms behind Conformational Transitions of the Influenza Virus Hemagglutinin Membrane Anchor
por: Michalski, Michal, et al.
Publicado: (2023)

Universal stabilization of the influenza hemagglutinin by structure-based redesign of the pH switch regions
por: Milder, Fin J., et al.
Publicado: (2022)

Hemagglutinin Sequence Conservation Guided Stem Immunogen Design from Influenza A H3 Subtype
por: Mallajosyula, V. Vamsee Aditya, et al.
Publicado: (2015)

Diagnostic Potential of Recombinant scFv Antibodies Generated Against Hemagglutinin Protein of Influenza A Virus
por: Rajput, Roopali, et al.
Publicado: (2015)

Comparison of the Protective Efficacy of Neutralizing Epitopes of 2009 Pandemic H1N1 Influenza Hemagglutinin
por: Peng, Bo, et al.
Publicado: (2017)

Conformational Stability of the Hemagglutinin of H5N1 Influenza A Viruses Influences Susceptibility to Broadly Neutralizing Stem Antibodies
por: Wang, Wei, et al.
Publicado: (2018)

Stability of the Influenza Virus Hemagglutinin Protein Correlates with Evolutionary Dynamics
por: Klein, Eili Y., et al.
Publicado: (2018)

Large-Scale Analysis of B-Cell Epitopes on Influenza Virus Hemagglutinin – Implications for Cross-Reactivity of Neutralizing Antibodies
por: Sun, Jing, et al.
Publicado: (2014)

Influenza Vaccination Results in Differential Hemagglutinin Stalk-Specific Fc-Mediated Functions in Individuals Living With or Without HIV
por: Motsoeneng, Boitumelo M., et al.
Publicado: (2022)

Functional significance of the hemadsorption activity of influenza virus neuraminidase and its alteration in pandemic viruses
por: Uhlendorff, Jennifer, et al.
Publicado: (2009)

In vitro and in vivo Effects of Lactate on Metabolism and Cytokine Production of Human Primary PBMCs and Monocytes
por: Ratter, Jacqueline M., et al.
Publicado: (2018)

Functional Enrichment and Analysis of Antigen-Specific Memory B Cell Antibody Repertoires in PBMCs
por: Waltari, Eric, et al.
Publicado: (2019)

A Carboxy-Terminal Trimerization Domain Stabilizes Conformational Epitopes on the Stalk Domain of Soluble Recombinant Hemagglutinin Substrates
por: Krammer, Florian, et al.
Publicado: (2012)

Administration of Multivalent Influenza Virus Recombinant Hemagglutinin Vaccine in Combination-Adjuvant Elicits Broad Reactivity Beyond the Vaccine Components
por: Hernandez-Davies, Jenny E., et al.
Publicado: (2021)

Identification of Differential Responses of Goat PBMCs to PPRV Virulence Using a Multi-Omics Approach
por: Eloiflin, Roger-Junior, et al.
Publicado: (2021)

Glucocorticoid receptor hypersensitivity enhances inflammatory signaling and inhibits cell cycle progression in porcine PBMCs
por: Li, Zhiwei, et al.
Publicado: (2022)

Inferring Stabilizing Mutations from Protein Phylogenies: Application to Influenza Hemagglutinin
por: Bloom, Jesse D., et al.
Publicado: (2009)

Development of molecular clamp stabilized hemagglutinin vaccines for Influenza A viruses
por: McMillan, Christopher L. D., et al.
Publicado: (2021)

Pandemic H1N1 Influenza Infection and Vaccination in Humans Induces Cross-Protective Antibodies that Target the Hemagglutinin Stem
por: Thomson, C. A., et al.
Publicado: (2012)

Vaccination With Viral Vectors Expressing Chimeric Hemagglutinin, NP and M1 Antigens Protects Ferrets Against Influenza Virus Challenge
por: McMahon, Meagan, et al.
Publicado: (2019)

Mutation S110L of H1N1 Influenza Virus Hemagglutinin: A Potent Determinant of Attenuation in the Mouse Model
por: Nieto, Amelia, et al.
Publicado: (2019)

Induction of Cross-Reactive and Protective Antibody Responses After DNA Vaccination With MHCII-Targeted Stem Domain From Influenza Hemagglutinin
por: Grødeland, Gunnveig, et al.
Publicado: (2020)

Mosaic Hemagglutinin-Based Whole Inactivated Virus Vaccines Induce Broad Protection Against Influenza B Virus Challenge in Mice
por: Liu, Yonghong, et al.
Publicado: (2021)

Erratum: Administration of Multivalent Influenza Virus Recombinant Hemagglutinin Vaccine in Combination-Adjuvant Elicits Broad Reactivity Beyond the Vaccine Components
Publicado: (2021)

Self-Amplifying Pestivirus Replicon RNA Encoding Influenza Virus Nucleoprotein and Hemagglutinin Promote Humoral and Cellular Immune Responses in Pigs
por: Démoulins, Thomas, et al.
Publicado: (2021)

Development of Lentiviral Vectors Pseudotyped With Influenza B Hemagglutinins: Application in Vaccine Immunogenicity, mAb Potency, and Sero-Surveillance Studies
por: Ferrara, Francesca, et al.
Publicado: (2021)

Dysregulated miRNAome and Proteome of PPRV Infected Goat PBMCs Reveal a Coordinated Immune Response
por: Khanduri, Alok, et al.
Publicado: (2018)

The 2(nd) sialic acid-binding site of influenza A virus neuraminidase is an important determinant of the hemagglutinin-neuraminidase-receptor balance
por: Du, Wenjuan, et al.
Publicado: (2019)

Nanoparticles of conformation-stabilized canine distemper virus hemagglutinin are highly immunogenic and induce robust immunity
por: Dong, Jingjian, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_m5emq6056ps478f5l0mqsik9tu