The CCR5 Gene Edited CD34(+)CD90(+) Hematopoietic Stem Cell Population Serves as an Optimal Graft Source for HIV Gene Therapy

Transplantation of allogenic hematopoietic stem and progenitor cells (HSPCs) with C-C chemokine receptor type 5 (CCR5) Δ32 genotype generates HIV-1 resistant immune cells. CCR5 gene edited autologous HSPCs can be a potential alternative to hematopoietic stem cell transplantation (HSCT) from HLA-matc...

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Detalles Bibliográficos
Autores principales: Karuppusamy, Karthik V., Demosthenes, John Paul, Venkatesan, Vigneshwaran, Christopher, Abisha Crystal, Babu, Prathibha, Azhagiri, Manojkumar K., Jacob, Annlin, Ramalingam, Veena Vadhini, Rangaraj, Sumathi, Murugesan, Mohankumar Kumarasamypet, Marepally, Srujan Kumar, Varghese, George M., Srivastava, Alok, Kannangai, Rajesh, Thangavel, Saravanabhavan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8963924/
https://www.ncbi.nlm.nih.gov/pubmed/35359982
http://dx.doi.org/10.3389/fimmu.2022.792684

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8963924/
https://www.ncbi.nlm.nih.gov/pubmed/35359982
http://dx.doi.org/10.3389/fimmu.2022.792684

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