Deferoxamine Alleviates Osteoarthritis by Inhibiting Chondrocyte Ferroptosis and Activating the Nrf2 Pathway

Objective: Osteoarthritis (OA) is a common disease with a complex pathology including mechanical load, inflammation, and metabolic factors. Chondrocyte ferroptosis contributes to OA progression. Because iron deposition is a major pathological event in ferroptosis, deferoxamine (DFO), an effective ir...

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Detalles Bibliográficos
Autores principales: Guo, Zhou, Lin, Jiamin, Sun, Kai, Guo, Jiayou, Yao, Xudong, Wang, Genchun, Hou, Liangcai, Xu, Jingting, Guo, Jiachao, Guo, Fengjing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964096/
https://www.ncbi.nlm.nih.gov/pubmed/35359876
http://dx.doi.org/10.3389/fphar.2022.791376

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964096/
https://www.ncbi.nlm.nih.gov/pubmed/35359876
http://dx.doi.org/10.3389/fphar.2022.791376

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