Cataract-Causing S93R Mutant Destabilized Structural Conformation of βB1 Crystallin Linking With Aggregates Formation and Cellular Viability

Cataract, opacity of the eye lens, is the leading cause of visual impairment worldwide. The crucial pathogenic factors that cause cataract are misfolding and aggregation of crystallin protein. βB1‐crystallin, which is the most abundant water‐soluble protein in mammalian lens, is essential for lens t...

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Detalles Bibliográficos
Autores principales: Ren, Ling, Hu, Lidan, Zhang, Ying, Liu, Jian, Xu, Wanyue, Wu, Wei, Xu, Jingjie, Chen, Xiangjun, Yao, Ke, Yu, Yibo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964140/
https://www.ncbi.nlm.nih.gov/pubmed/35359596
http://dx.doi.org/10.3389/fmolb.2022.844719

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964140/
https://www.ncbi.nlm.nih.gov/pubmed/35359596
http://dx.doi.org/10.3389/fmolb.2022.844719

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