Cancer-derived C-terminus-extended p53 mutation confers dominant-negative effect on its wild-type counterpart

The vast majority of p53 missense mutants lose the wild-type (wt) function and/or exert ‘dominant-negative’ effects on their wt counterpart. Here, we identify a novel form of p53 mutation with an extended C-terminus (p53 long C-terminus, p53LC) in a variety of human cancers. Interestingly, the two r...

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Detalles Bibliográficos
Autores principales: Huang, Shibo, Cao, Bo, Wang, Jieqiong, Zhang, Yiwei, Ledet, Elisa, Sartor, Oliver, Xiong, Yuqin, Zeng, Shelya X, Lu, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964174/
https://www.ncbi.nlm.nih.gov/pubmed/34918105
http://dx.doi.org/10.1093/jmcb/mjab078

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964174/
https://www.ncbi.nlm.nih.gov/pubmed/34918105
http://dx.doi.org/10.1093/jmcb/mjab078

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