Cargando…
Cancer-derived C-terminus-extended p53 mutation confers dominant-negative effect on its wild-type counterpart
The vast majority of p53 missense mutants lose the wild-type (wt) function and/or exert ‘dominant-negative’ effects on their wt counterpart. Here, we identify a novel form of p53 mutation with an extended C-terminus (p53 long C-terminus, p53LC) in a variety of human cancers. Interestingly, the two r...
| Autores principales: | , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2021
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964174/ https://www.ncbi.nlm.nih.gov/pubmed/34918105 http://dx.doi.org/10.1093/jmcb/mjab078 |