IP-Se-06, a Selenylated Imidazo[1,2-a]pyridine, Modulates Intracellular Redox State and Causes Akt/mTOR/HIF-1α and MAPK Signaling Inhibition, Promoting Antiproliferative Effect and Apoptosis in Glioblastoma Cells

Glioblastoma multiforme (GBM) is a notably lethal brain tumor associated with high proliferation rate and therapeutic resistance, while currently effective treatment options are still lacking. Imidazo[1,2-a]pyridine derivatives and organoselenium compounds are largely used in medicinal chemistry and...

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Detalles Bibliográficos
Autores principales: dos Santos, Daniela C., Rafique, Jamal, Saba, Sumbal, Grinevicius, Valdelúcia M. A. S., Filho, Danilo W., Zamoner, Ariane, Braga, Antonio L., Pedrosa, Rozangela C., Ourique, Fabiana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964227/
https://www.ncbi.nlm.nih.gov/pubmed/35360199
http://dx.doi.org/10.1155/2022/3710449

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964227/
https://www.ncbi.nlm.nih.gov/pubmed/35360199
http://dx.doi.org/10.1155/2022/3710449

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