Loss-of-function Mutations K11E or E271K Lead to Novel Tumor Suppression, Implicate Nucleolar Helicase DDX24 Oncogenicity

Purpose: Mutations (K11E or E271K) of DEAD-box RNA helicase 24 (DDX24) were related to multi-organ venous lymphatic malformation syndrome (MOVLD). However, the relationship between these mutations and DDX24-function still remains unknown. Understanding whether K11E and E271K cause “loss-of-function”...

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Detalles Bibliográficos
Autores principales: Li, Xinglin, Chen, Xiaoyun, Gao, Jiebing, Xian, Jianzhong, Li, Zhijun, Bi, Lei, Yang, Min, Yang, Shuai, Jin, Hongjun, Shan, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964322/
https://www.ncbi.nlm.nih.gov/pubmed/35370459
http://dx.doi.org/10.7150/ijms.67840

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964322/
https://www.ncbi.nlm.nih.gov/pubmed/35370459
http://dx.doi.org/10.7150/ijms.67840

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