A murine mesenchymal stem cell model for initiating events in osteosarcomagenesis points to CDK4/CDK6 inhibition as a therapeutic target

Osteosarcoma is a high-grade bone-forming neoplasm, with a complex genome. Tumours frequently show chromothripsis, many deletions, translocations and copy number alterations. Alterations in the p53 or Rb pathway are the most common genetic alterations identified in osteosarcoma. Using spontaneously...

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Detalles Bibliográficos
Autores principales: Franceschini, Natasja, Gaeta, Raffaele, Krimpenfort, Paul, Briaire-de Bruijn, Inge, Kruisselbrink, Alwine B., Szuhai, Karoly, Palubeckaitė, Ieva, Cleton-Jansen, Anne-Marie, Bovée, Judith V. M. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964417/
https://www.ncbi.nlm.nih.gov/pubmed/34921235
http://dx.doi.org/10.1038/s41374-021-00709-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964417/
https://www.ncbi.nlm.nih.gov/pubmed/34921235
http://dx.doi.org/10.1038/s41374-021-00709-z

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