Tcap Deficiency in Zebrafish Leads to ROS Production and Mitophagy, and Idebenone Improves its Phenotypes

Limb-girdle muscular dystrophy 2G (LGMD2G) is a subtype of limb-girdle muscular dystrophy. However, the disease’s mechanisms are still not fully understood, and no established therapeutic targets have been found. Using a morpholino-based knockdown approach, we established an LGMD2G zebrafish model....

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Detalles Bibliográficos
Autores principales: Lv, Xiaoqing, Zhang, Rui, Xu, Ling, Wang, Guangyu, Yan, Chuanzhu, Lin, Pengfei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964517/
https://www.ncbi.nlm.nih.gov/pubmed/35372370
http://dx.doi.org/10.3389/fcell.2022.836464

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964517/
https://www.ncbi.nlm.nih.gov/pubmed/35372370
http://dx.doi.org/10.3389/fcell.2022.836464

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