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Phage peptides mediate precision base editing with focused targeting window

Base editors (BEs) are genome engineering tools that can generate nucleotide substitutions without introducing double-stranded breaks (DSBs). A variety of strategies have been developed to improve the targeting scope and window of BEs. In a previous study, we found that a bacteriophage-derived pepti...

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Detalles Bibliográficos
Autores principales: Jia, Kun, Cui, Yan-ru, Huang, Shisheng, Yu, Peihong, Lian, Zhengxing, Ma, Peixiang, Liu, Jia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964698/
https://www.ncbi.nlm.nih.gov/pubmed/35351888
http://dx.doi.org/10.1038/s41467-022-29365-7