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APOE-ε4 modulates the association among plasma Aβ(42)/Aβ(40), vascular diseases, neurodegeneration and cognitive decline in non-demented elderly adults

Including apolipoprotein E-ε4 (APOE-ε4) status and older age into consideration may increase the accuracy of plasma Aβ(42)/Aβ(40) detecting Aβ+ individuals, but the rationale behind this remains to be fully understood. Besides, both Aβ pathology and vascular diseases are related to neurodegeneration...

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Detalles Bibliográficos
Autores principales: Shi, Dai, Xie, Siwei, Li, Anqi, Wang, Qingyong, Guo, Hongbo, Han, Ying, Xu, Huaxi, Gan, Wen-Biao, Zhang, Lei, Guo, Tengfei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964707/
https://www.ncbi.nlm.nih.gov/pubmed/35351867
http://dx.doi.org/10.1038/s41398-022-01899-w