In Vivo Pravastatin Treatment Reverses Hypercholesterolemia Induced Mitochondria-Associated Membranes Contact Sites, Foam Cell Formation, and Phagocytosis in Macrophages

Statins are successful drugs used to treat hypercholesterolemia, a primary cause of atherosclerosis. In this work, we investigated how hypercholesterolemia and pravastatin treatment impact macrophage and mitochondria functions, the key cell involved in atherogenesis. By comparing bone marrow-derived...

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Detalles Bibliográficos
Autores principales: Assis, Leandro Henrique de Paula, Dorighello, Gabriel de Gabriel, Rentz, Thiago, de Souza, Jane Cristina, Vercesi, Aníbal Eugênio, de Oliveira, Helena Coutinho Franco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8965079/
https://www.ncbi.nlm.nih.gov/pubmed/35372506
http://dx.doi.org/10.3389/fmolb.2022.839428

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8965079/
https://www.ncbi.nlm.nih.gov/pubmed/35372506
http://dx.doi.org/10.3389/fmolb.2022.839428

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