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Positive Effects of Neutrophil Elastase Inhibitor (Sivelestat) on Gut Microbiome and Metabolite Profiles of Septic Rats

BACKGROUND: Neutrophil elastase (NE) is associated with sepsis occurrence and progression. We hypothesized that the NE inhibitor Sivelestat might modulate abnormal gut microbiota and metabolites during sepsis. METHODS: Sixty Sprague-Dawley (SD) rats were randomly divided into sham control (SC), seps...

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Detalles Bibliográficos
Autores principales:	Sun, Yali, Ding, Xianfei, Cui, Yuqing, Li, Hongyi, Wang, Dong, Liang, Huoyan, Liu, Shaohua, Zhang, Xiaojuan, Wang, Haixu, Sun, Tongwen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cellular and Infection Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8965314/ https://www.ncbi.nlm.nih.gov/pubmed/35372122 http://dx.doi.org/10.3389/fcimb.2022.818391

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