Cargando…

Structural Dissection of the First Events Following Membrane Binding of the Islet Amyloid Polypeptide

The islet amyloid polypeptide (IAPP) is the main constituent of the amyloid fibrils found in the pancreas of type 2 diabetes patients. The aggregation of IAPP is known to cause cell death, where the cell membrane plays a dual role: being a catalyst of IAPP aggregation and being the target of IAPP to...

Descripción completa

Detalles Bibliográficos
Autores principales:	Khemtemourian, Lucie, Fatafta, Hebah, Davion, Benoit, Lecomte, Sophie, Castano, Sabine, Strodel, Birgit
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8965455/ https://www.ncbi.nlm.nih.gov/pubmed/35372496 http://dx.doi.org/10.3389/fmolb.2022.849979

Ejemplares similares

The Effect of Cholesterol on Membrane-Bound Islet Amyloid Polypeptide
por: Christensen, Mikkel, et al.
Publicado: (2021)

Studies on alpha-synuclein and islet amyloid polypeptide interaction
por: Wang, Ye, et al.
Publicado: (2023)

Contribution of the 12–17 hydrophobic region of islet amyloid polypeptide in self-assembly and cytotoxicity
por: Fortier, Mathilde, et al.
Publicado: (2022)

Membrane-Catalyzed Aggregation of Islet Amyloid Polypeptide Is Dominated by Secondary Nucleation
por: Elenbaas, Barend O. W., et al.
Publicado: (2022)

Recent Insight in Islet Amyloid Polypeptide Morphology, Structure, Membrane Interaction, and Toxicity in Type 2 Diabetes
por: Khemtemourian, Lucie, et al.
Publicado: (2016)

Molecular Structure, Membrane Interactions, and Toxicity of the Islet Amyloid Polypeptide in Type 2 Diabetes Mellitus
por: Caillon, Lucie, et al.
Publicado: (2016)

The role of the disulfide bond in the interaction of islet amyloid polypeptide with membranes
por: Khemtémourian, Lucie, et al.
Publicado: (2010)

Amyloid-β peptide dimers undergo a random coil to β-sheet transition in the aqueous phase but not at the neuronal membrane
por: Fatafta, Hebah, et al.
Publicado: (2021)

Comparative molecular dynamics simulations of pathogenic and non-pathogenic huntingtin protein monomers and dimers
por: Khaled, Mohammed, et al.
Publicado: (2023)

Recent Insights in Islet Amyloid Polypeptide-Induced Membrane Disruption and Its Role in β-Cell Death in Type 2 Diabetes Mellitus
por: Khemtémourian, Lucie, et al.
Publicado: (2008)

β-Hairpin Peptide Mimics Decrease Human Islet Amyloid Polypeptide (hIAPP) Aggregation
por: Lesma, Jacopo, et al.
Publicado: (2021)

Structural polymorphism of the low-complexity C-terminal domain of TDP-43 amyloid aggregates revealed by solid-state NMR
por: Shenoy, Jayakrishna, et al.
Publicado: (2023)

Selective Inhibition of HDAC1 by Macrocyclic Polypeptide for the Treatment of Glioblastoma: A Binding Mechanistic Analysis Based on Molecular Dynamics
por: Zhang, Yang, et al.
Publicado: (2020)

Characterizing Heparin Tetrasaccharides Binding to Amyloid-Beta Peptide
por: Zhou, Xiang, et al.
Publicado: (2022)

Multi-layered molecular mechanisms of polypeptide holding, unfolding and disaggregation by HSP70/HSP110 chaperones
por: Finka, Andrija, et al.
Publicado: (2015)

Albumin Alters the Conformational Ensemble of Amyloid-β by Promiscuous Interactions: Implications for Amyloid Inhibition
por: Xie, Huisi, et al.
Publicado: (2021)

Islet Amyloid Polypeptide: Structure, Function, and Pathophysiology
por: Akter, Rehana, et al.
Publicado: (2016)

β-Hairpin of Islet Amyloid Polypeptide Bound to an Aggregation Inhibitor
por: Mirecka, Ewa A., et al.
Publicado: (2016)

Efficacy of IAPP suppression in mouse and human islets by GLP-1 analogue conjugated antisense oligonucleotide
por: Gurlo, Tatyana, et al.
Publicado: (2023)

Relevance of Amorphous and Amyloid-Like Aggregates of the p53 Core Domain to Loss of its DNA-Binding Activity
por: Hibino, Emi, et al.
Publicado: (2022)

The kinetics of islet amyloid polypeptide phase-separated system and hydrogel formation are critically influenced by macromolecular crowding
por: Pytowski, Lior, et al.
Publicado: (2021)

Synergism between a foldase and an unfoldase: reciprocal dependence between the thioredoxin-like activity of DnaJ and the polypeptide-unfolding activity of DnaK
por: Mattoo, Rayees U. H., et al.
Publicado: (2014)

Glucotoxicity Activation of IL6 and IL11 and Subsequent Induction of Fibrosis May Be Involved in the Pathogenesis of Islet Dysfunction
por: Lu, Liqin, et al.
Publicado: (2021)

Differential effects of glycation on protein aggregation and amyloid formation
por: Iannuzzi, Clara, et al.
Publicado: (2014)

Prion Amyloid Polymorphs – The Tag Might Change It All
por: Bousset, Luc, et al.
Publicado: (2020)

AFM Probing of Amyloid-Beta 42 Dimers and Trimers
por: Maity, Sibaprasad, et al.
Publicado: (2020)

The role of heat shock proteins in preventing amyloid toxicity
por: Törner, Ricarda, et al.
Publicado: (2022)

Amyloid fibrils degradation: the pathway to recovery or aggravation of the disease?
por: Sulatsky, Maksim I., et al.
Publicado: (2023)

Oligomerization by co-assembly of β-amyloid and α-synuclein
por: Kim, Jin Ryoun
Publicado: (2023)

The Role of the 14–20 Domain of the Islet Amyloid Polypeptide in Amyloid Formation
por: Gilead, Sharon, et al.
Publicado: (2008)

Islet amyloid polypeptide does not suppress pancreatic cancer
por: Taylor, Austin J., et al.
Publicado: (2023)

Dissecting the Extracellular Complexity of Neuromuscular Junction Organizers
por: Guarino, Salvatore R., et al.
Publicado: (2020)

Physicochemical characteristics of structurally determined metabolite-protein and drug-protein binding events with respect to binding specificity
por: Korkuć, Paula, et al.
Publicado: (2015)

Are Amyloid Fibrils RNA-Traps? A Molecular Dynamics Perspective
por: Meli, Massimiliano, et al.
Publicado: (2018)

Secondary Nucleation and the Conservation of Structural Characteristics of Amyloid Fibril Strains
por: Hadi Alijanvand, Saeid, et al.
Publicado: (2021)

Editorial: Oligomerization and fibrillation of amyloid peptides: Mechanism, toxicity and inhibition
por: Qian, Zhenyu, et al.
Publicado: (2022)

Amyloid oligomers as on-pathway precursors or off-pathway competitors of fibrils
por: Muschol, Martin, et al.
Publicado: (2023)

Editorial: Oligomers in amyloid-associated diseases—structural properties and toxicity
por: Vassallo, Neville, et al.
Publicado: (2023)

Yeast Models for the Study of Amyloid-Associated Disorders and Development of Future Therapy
por: Rencus-Lazar, Sigal, et al.
Publicado: (2019)

Molecular Dynamics of Lysozyme Amyloid Polymorphs Studied by Incoherent Neutron Scattering
por: Matsuo, Tatsuhito, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_bub02sl7atcg1gqpo3f85rhuj2