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PINCH-1 promotes IGF-1 receptor expression and skin cancer progression through inhibition of the GRB10-NEDD4 complex

Background: Insulin-like growth factor 1 receptor (IGF-1R) expression and signaling play important roles in promotion of skin cancer progression. Identification of signaling pathways that regulate IGF-1R is crucial for understanding the pathogenesis and therapeutic treatment of skin cancer. Methods:...

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Detalles Bibliográficos
Autores principales: Wang, Xiaoxiao, Wang, Rong, Jiang, Kun, Zhu, Maohua, Guo, Ling, Wu, Chuanyue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8965486/
https://www.ncbi.nlm.nih.gov/pubmed/35401828
http://dx.doi.org/10.7150/thno.70744