Cargando…

The AlkB Family: Potential Prognostic Biomarkers and Therapeutic Targets in Glioblastoma

The AlkB family of Fe (II) and α-ketoglutarate-dependent dioxygenases works by removing alkyl substituents from alkylation-damaged nucleic acid bases through oxidative dealkylation, subsequently affecting tumor progression and patient prognosis. However, the specific roles of the AlkB family in Glio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Feng, Songshan, Xu, Zhijie, Peng, Jinwu, Zhang, Mingyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8965608/ https://www.ncbi.nlm.nih.gov/pubmed/35371987 http://dx.doi.org/10.3389/fonc.2022.847821

Ejemplares similares

The role of demethylase AlkB homologs in cancer
por: Li, Qiao, et al.
Publicado: (2023)

Expression and molecular profiles of the AlkB family in ovarian serous carcinoma
por: Cai, Yuan, et al.
Publicado: (2021)

The bioinformatics and experimental analysis of AlkB family for prognosis and immune cell infiltration in hepatocellular carcinoma
por: Peng, Bi, et al.
Publicado: (2021)

Bioinformatic mapping of AlkB homology domains in viruses
por: Bratlie, Marit S, et al.
Publicado: (2005)

Structure and mechanism of the alkane-oxidizing enzyme AlkB
por: Guo, Xue, et al.
Publicado: (2023)

Integrin Beta 5 Is a Prognostic Biomarker and Potential Therapeutic Target in Glioblastoma
por: Zhang, Lu-yang, et al.
Publicado: (2019)

ALK receptor activation, ligands and therapeutic targeting in glioblastoma and in other cancers
por: Wellstein, Anton
Publicado: (2012)

Genome-Wide Identification and Characterization of the AlkB Gene Family in Sweet Orange (Citrus sinensis)
por: Huang, Aijun, et al.
Publicado: (2022)

Viral AlkB proteins repair RNA damage by oxidative demethylation
por: van den Born, Erwin, et al.
Publicado: (2008)

Novel AlkB Dioxygenases—Alternative Models for In Silico and In Vivo Studies
por: Mielecki, Damian, et al.
Publicado: (2012)

An Overview of the Electron-Transfer Proteins That Activate Alkane Monooxygenase (AlkB)
por: Williams, Shoshana C., et al.
Publicado: (2022)

Role of the Demethylase AlkB Homolog H5 in the Promotion of Dentinogenesis
por: Tian, Cheng, et al.
Publicado: (2022)

Structure of AlkB–AlkG shows details of alkane terminal C–H selectivity and functionalization
Publicado: (2023)

RecA stimulates AlkB-mediated direct repair of DNA adducts
por: Shivange, Gururaj, et al.
Publicado: (2016)

NAIL-MS reveals the repair of 2-methylthiocytidine by AlkB in E. coli
por: Reichle, Valentin F., et al.
Publicado: (2019)

Structural basis for substrate discrimination by E. coli repair enzyme, AlkB
por: Jayanth, Namrata, et al.
Publicado: (2018)

Phylogenomic identification of five new human homologs of the DNA repair enzyme AlkB
por: Kurowski, Michal A, et al.
Publicado: (2003)

AlkB RNA demethylase homologues and N (6) ‐methyladenosine are involved in Potyvirus infection
por: Yue, Jianying, et al.
Publicado: (2022)

Bioinformatics and functional analysis define four distinct groups of AlkB DNA-dioxygenases in bacteria
por: van den Born, Erwin, et al.
Publicado: (2009)

Alkane hydroxylase gene (alkB) phylotype composition and diversity in northern Gulf of Mexico bacterioplankton
por: Smith, Conor B., et al.
Publicado: (2013)

The Use of a Combination of alkB Primers to Better Characterize the Distribution of Alkane-Degrading Bacteria
por: Jurelevicius, Diogo, et al.
Publicado: (2013)

Exocyclic Carbons Adjacent to the N(6) of Adenine are Targets for Oxidation by the Escherichia coli Adaptive Response Protein AlkB
por: Li, Deyu, et al.
Publicado: (2012)

The DNA-repair protein AlkB, EGL-9, and leprecan define new families of 2-oxoglutarate- and iron-dependent dioxygenases
por: Aravind, L, et al.
Publicado: (2001)

Standardization of inducer-activated broad host range expression modules: debugging and refactoring an alkane-responsive AlkS/P(alkB) device
por: Arce-Rodríguez, Alejandro, et al.
Publicado: (2021)

GPo1 alkB gene expression for improvement of the degradation of diesel oil by a bacterial consortium
por: Luo, Qun, et al.
Publicado: (2015)

AlkB homolog 3-mediated tRNA demethylation promotes protein synthesis in cancer cells
por: Ueda, Yuko, et al.
Publicado: (2017)

Activity of alkanmonooxygenase alkB gene in strains of hydrocarbon-oxidizing bacteria isolated from petroleum products
por: Shapiro, T.N., et al.
Publicado: (2022)

Dataset of 16S rRNA and alkB genes in hydrocarbon polluted soils of Kuwait as revealed by Pyrosequencing
por: Al-Momin, Sabah, et al.
Publicado: (2022)

LASSO-based screening for potential prognostic biomarkers associated with glioblastoma
por: Tian, Yin, et al.
Publicado: (2023)

GFAPδ: A Promising Biomarker and Therapeutic Target in Glioblastoma
por: Radu, Roxana, et al.
Publicado: (2022)

Kinetic studies of Escherichia coli AlkB using a new fluorescence-based assay for DNA demethylation
por: Roy, Todd W., et al.
Publicado: (2007)

Structural and Mutational Analysis of Escherichia coli AlkB Provides Insight into Substrate Specificity and DNA Damage Searching
por: Holland, Paul J., et al.
Publicado: (2010)

Alternative Pathway for the Reaction Catalyzed by DNA Dealkylase AlkB from Ab Initio QM/MM Calculations
por: Fang, Dong, et al.
Publicado: (2014)

The Prognostic and Therapeutic Potential of LRIG3 and Soluble LRIG3 in Glioblastoma
por: Cheng, Fangling, et al.
Publicado: (2019)

Pseudomonas putida AlkA and AlkB Proteins Comprise Different Defense Systems for the Repair of Alkylation Damage to DNA – In Vivo, In Vitro, and In Silico Studies
por: Mielecki, Damian, et al.
Publicado: (2013)

TP53 regulates human AlkB homologue 2 expression in glioma resistance to Photofrin-mediated photodynamic therapy
por: Lee, S Y, et al.
Publicado: (2010)

Mechanism of Repair of Acrolein- and Malondialdehyde-Derived Exocyclic Guanine Adducts by the α-Ketoglutarate/Fe(II) Dioxygenase AlkB
por: Singh, Vipender, et al.
Publicado: (2014)

A novel alkane monooxygenase (alkB) clade revealed by massive genomic survey and its dissemination association with IS elements
por: Wang, Shaojing, et al.
Publicado: (2022)

Corrigendum: The Prognostic and Therapeutic Potential of LRIG3 and Soluble LRIG3 in Glioblastoma
por: Cheng, Fangling, et al.
Publicado: (2020)

Transcriptomics-Guided Personalized Prescription of Targeted Therapeutics for Metastatic ALK-Positive Lung Cancer Case Following Recurrence on ALK Inhibitors
por: Poddubskaya, Elena, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_farcmel06s6a19mq6sar10v9nb