Cargando…

Tissue Damage, Not Infection, Triggers Hepatic Unfolded Protein Response in an Experimental Rat Peritonitis Model

BACKGROUND: Abdominal surgery is an efficient treatment of intra-abdominal sepsis. Surgical trauma and peritoneal infection lead to the activation of multiple pathological pathways. The liver is particularly susceptible to injury under septic conditions. Liver function is impaired when pathological...

Descripción completa

Detalles Bibliográficos
Autores principales:	Müllebner, Andrea, Herminghaus, Anna, Miller, Ingrid, Kames, Martina, Luís, Andreia, Picker, Olaf, Bauer, Inge, Kozlov, Andrey V., Duvigneau, Johanna Catharina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8965740/ https://www.ncbi.nlm.nih.gov/pubmed/35372445 http://dx.doi.org/10.3389/fmed.2022.785285

Ejemplares similares

Interaction between Mitochondrial Reactive Oxygen Species, Heme Oxygenase, and Nitric Oxide Synthase Stimulates Phagocytosis in Macrophages
por: Müllebner, Andrea, et al.
Publicado: (2018)

Heme Degradation by Heme Oxygenase Protects Mitochondria but Induces ER Stress via Formed Bilirubin
por: Müllebner, Andrea, et al.
Publicado: (2015)

Cannabidiol Protects Dopaminergic Neurons in Mesencephalic Cultures against the Complex I Inhibitor Rotenone Via Modulation of Heme Oxygenase Activity and Bilirubin
por: Duvigneau, Johanna Catharina, et al.
Publicado: (2020)

Editorial: Impaired oxygen delivery in experimental disease models: Pathogenesis, diagnostics and treatment strategies
por: Weihs, Wolfgang, et al.
Publicado: (2022)

Systemic Effects of mitoTEMPO upon Lipopolysaccharide Challenge Are Due to Its Antioxidant Part, While Local Effects in the Lung Are Due to Triphenylphosphonium
por: Weidinger, Adelheid, et al.
Publicado: (2022)

Experimental data suggesting that inflammation mediated rat liver mitochondrial dysfunction results from secondary hypoxia rather than from direct effects of inflammatory mediators
por: Weidinger, Adelheid, et al.
Publicado: (2013)

Sub-therapeutic vasopressin but not therapeutic vasopressin improves gastrointestinal microcirculation in septic rats: A randomized, placebo-controlled, blinded trial
por: Schulz, Jan, et al.
Publicado: (2021)

Time-related changes in hepatic and colonic mitochondrial oxygen consumption after abdominal infection in rats
por: Herminghaus, Anna, et al.
Publicado: (2019)

Pathological Impact of the Interaction of NO and CO with Mitochondria in Critical Care Diseases
por: Duvigneau, J. Catharina, et al.
Publicado: (2017)

Nitroglycerin and Iloprost Improve Mitochondrial Function in Colon Homogenate Without Altering the Barrier Integrity of Caco-2 Monolayers
por: Herminghaus, Anna, et al.
Publicado: (2018)

Pravastatin and Gemfibrozil Modulate Differently Hepatic and Colonic Mitochondrial Respiration in Tissue Homogenates from Healthy Rats
por: Herminghaus, Anna, et al.
Publicado: (2019)

Sodium Thiosulfate Improves Intestinal and Hepatic Microcirculation Without Affecting Mitochondrial Function in Experimental Sepsis
por: Schulz, Jan, et al.
Publicado: (2021)

Role of Heme Oxygenase as a Modulator of Heme-Mediated Pathways
por: Duvigneau, J. Catharina, et al.
Publicado: (2019)

Indomethacin Increases the Efficacy of Oxygen Utilization of Colonic Mitochondria and Uncouples Hepatic Mitochondria in Tissue Homogenates From Healthy Rats
por: Herminghaus, Anna, et al.
Publicado: (2020)

A Toolbox to Investigate the Impact of Impaired Oxygen Delivery in Experimental Disease Models
por: Hof, Stefan, et al.
Publicado: (2022)

Topical Melatonin Improves Gastric Microcirculatory Oxygenation During Hemorrhagic Shock in Dogs but Does Not Alter Barrier Integrity of Caco-2 Monolayers
por: Truse, Richard, et al.
Publicado: (2020)

Regional hypothermia improves gastric microcirculatory oxygenation during hemorrhage in dogs
por: Truse, Richard, et al.
Publicado: (2019)

Exogenous vasopressin dose-dependently modulates gastric microcirculatory oxygenation in dogs via V1A receptor
por: Truse, Richard, et al.
Publicado: (2019)

Porcine CD8α(dim/-)NKp46(high) NK cells are in a highly activated state
por: Mair, Kerstin H, et al.
Publicado: (2013)

Local Mucosal CO(2) but Not O(2) Insufflation Improves Gastric and Oral Microcirculatory Oxygenation in a Canine Model of Mild Hemorrhagic Shock
por: Hof, Stefan, et al.
Publicado: (2022)

Radical Scavenging Is Not Involved in Thymoquinone-Induced Cell Protection in Neural Oxidative Stress Models
por: Krewenka, Christopher, et al.
Publicado: (2023)

0589. Pravastatin exerts opposite effects on splanchnic microcirculatory oxygenation during sham or septic conditions in an animal model of polymicrobial sepsis
por: Beck, C, et al.
Publicado: (2014)

Motor Cortex and Hippocampus Display Decreased Heme Oxygenase Activity 2 Weeks After Ventricular Fibrillation Cardiac Arrest in Rats
por: Warenits, Alexandra-Maria, et al.
Publicado: (2020)

CD27 expression discriminates porcine T helper cells with functionally distinct properties
por: Reutner, Katharina, et al.
Publicado: (2013)

Pravastatin Improves Colonic and Hepatic Microcirculatory Oxygenation during Sepsis without Affecting Mitochondrial Function and ROS Production in Rats
por: Kuebart, Anne, et al.
Publicado: (2023)

Containing the Damage of Unfolded Proteins
por: Gross, Liza
Publicado: (2006)

Porcine CD3(+)NKp46(+) Lymphocytes Have NK-Cell Characteristics and Are Present in Increased Frequencies in the Lungs of Influenza-Infected Animals
por: Mair, Kerstin H., et al.
Publicado: (2016)

Host-pathogen interplay at primary infection sites in pigs challenged with Actinobacillus pleuropneumoniae
por: Sassu, Elena L., et al.
Publicado: (2017)

Hypothermia Improves Oral and Gastric Mucosal Microvascular Oxygenation during Hemorrhagic Shock in Dogs
por: Vollmer, Christian, et al.
Publicado: (2013)

Adsorption and Unfolding of a Single Protein Triggers Nanoparticle Aggregation
por: Dominguez-Medina, Sergio, et al.
Publicado: (2016)

The Unfolded-Protein Response Triggers the Arthropod Immune Deficiency Pathway
por: Sidak-Loftis, Lindsay C., et al.
Publicado: (2022)

Metabolic stress promotes renal tubular inflammation by triggering the unfolded protein response
por: Fougeray, S, et al.
Publicado: (2011)

Rosmarinic Acid Inhibits Mitochondrial Damage by Alleviating Unfolded Protein Response
por: Cai, Guoen, et al.
Publicado: (2022)

Exploratory reference intervals on hematology and cellular immune system of multiparous Large White sows
por: Sipos, Wolfgang, et al.
Publicado: (2011)

Endoplasmic reticulum stress and the unfolded protein response in skeletal muscle of subjects suffering from peritoneal sepsis
por: Metzing, Uta Barbara, et al.
Publicado: (2022)

Measuring psychopathology as it unfolds in daily life: addressing key assumptions of intensive longitudinal methods in the TRAILS TRANS-ID study
por: Schreuder, Marieke J., et al.
Publicado: (2020)

ATM-associated signalling triggers the unfolded protein response and cell death in response to stress
por: Hotokezaka, Yuka, et al.
Publicado: (2020)

Cold Atmospheric Plasma Triggers Apoptosis via the Unfolded Protein Response in Melanoma Cells
por: Zimmermann, Tom, et al.
Publicado: (2023)

Pathogenesis of Multiple Organ Failure: The Impact of Systemic Damage to Plasma Membranes
por: Kozlov, Andrey V., et al.
Publicado: (2022)

Unfolding algorithms and tests using RooUnfold
por: Adye, Tim
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_t8oqfeehiqgq372ke5k9l973c0