A drug screen with approved compounds identifies amlexanox as a novel Wnt/β-catenin activator inducing lung epithelial organoid formation

BACKGROUND AND PURPOSE: Emphysema is an incurable disease characterized by loss of lung tissue leading to impaired gas exchange. Wnt/β-catenin signalling is reduced in emphysema, and exogenous activation of the pathway in experimental models in vivo and in human ex vivo lung tissue improves lung fun...

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Detalles Bibliográficos
Autores principales: Costa, Rita, Wagner, Darcy E., Doryab, Ali, De Santis, Martina M., Schorpp, Kenji, Rothenaigner, Ina, Lehmann, Mareike, Baarsma, Hoeke A., Liu, Xueping, Schmid, Otmar, Campillos, Monica, Yildirim, Ali Önder, Hadian, Kamyar, Königshoff, Melanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8965750/
https://www.ncbi.nlm.nih.gov/pubmed/34089180
http://dx.doi.org/10.1111/bph.15581

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8965750/
https://www.ncbi.nlm.nih.gov/pubmed/34089180
http://dx.doi.org/10.1111/bph.15581

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