Cargando…

Autophagy Blockage Reduces the Incidence of Pancreatic Ductal Adenocarcinoma in the Context of Mutant Trp53

Macroautophagy (hereafter referred to as autophagy) is a homeostatic process that preserves cellular integrity. In mice, autophagy regulates pancreatic ductal adenocarcinoma (PDAC) development in a manner dependent on the status of the tumor suppressor gene Trp53. Studies published so far have inves...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mainz, Laura, Sarhan, Mohamed A. F. E., Roth, Sabine, Sauer, Ursula, Maurus, Katja, Hartmann, Elena M., Seibert, Helen-Desiree, Rosenwald, Andreas, Diefenbacher, Markus E., Rosenfeldt, Mathias T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8965752/ https://www.ncbi.nlm.nih.gov/pubmed/35372352 http://dx.doi.org/10.3389/fcell.2022.785252

Ejemplares similares

The impact of p53 on DNA damage and metabolic activation of the environmental carcinogen benzo[a]pyrene: effects in Trp53(+/+), Trp53(+/–) and Trp53(−/−) mice
por: Krais, Annette M., et al.
Publicado: (2015)

Jdp2 downregulates Trp53 transcription to promote leukaemogenesis in the context of Trp53 heterozygosity
por: van der Weyden, L, et al.
Publicado: (2013)

Chemosensitivity to doxorubicin in primary cells derived from tumor of FVB/N-Trp53(tm1Hw1) with TALEN-mediated Trp53 mutant gene
por: Yun, Woobin, et al.
Publicado: (2023)

A case of nodular lymphocyte predominant Hodgkin lymphoma with unexpected EBV-latency type
por: Rosenfeldt, Mathias T., et al.
Publicado: (2020)

Silencing of Testin expression is a frequent event in spontaneous lymphomas from Trp53-mutant mice
por: Weeks, Robert J., et al.
Publicado: (2020)

Are Trp53 rescue of Brca1 embryonic lethality and Trp53/Brca1 breast cancer association related?
por: McAllister, Kimberly A, et al.
Publicado: (2002)

Role of the TRP Channels in Pancreatic Ductal Adenocarcinoma Development and Progression
por: Mesquita, Gonçalo, et al.
Publicado: (2021)

Differential Effects of Trp53 Alterations in Murine Colorectal Cancer
por: Betzler, Alexander M., et al.
Publicado: (2021)

Combined mutation of Vhl and Trp53 causes renal cysts and tumours in mice
por: Albers, Joachim, et al.
Publicado: (2013)

PTEN mutant non-small cell lung cancer require ATM to suppress pro-apoptotic signalling and evade radiotherapy
por: Fischer, Thomas, et al.
Publicado: (2022)

Immunohistochemical Characterization of a Renal Nephroblastoma in a Trp53-mutant and Prolyl Isomerase 1-deficient Mouse
por: Castiglioni, Vittoria, et al.
Publicado: (2013)

Mutant TRP53 exerts a target gene-selective dominant-negative effect to drive tumor development
por: Aubrey, Brandon J., et al.
Publicado: (2018)

Mesenchymal tumor cells drive adaptive resistance of Trp53(−/−) breast tumor cells to inactivated mutant Kras
por: van Weele, Linda J., et al.
Publicado: (2022)

Recurrent Alterations in the MAPK pathway in Sporadic Pyogenic Granuloma of Childhood
por: STROBEL, Katharina, et al.
Publicado: (2022)

The Trp53-Trp53inp1-Tnfrsf10b Pathway Regulates the Radiation Response of Mouse Spermatogonial Stem Cells
por: Ishii, Kei, et al.
Publicado: (2014)

USP28 enables oncogenic transformation of respiratory cells, and its inhibition potentiates molecular therapy targeting mutant EGFR, BRAF and PI3K
por: Prieto‐Garcia, Cristian, et al.
Publicado: (2022)

p53 Regulation by TRP2 Is Not Pervasive in Melanoma
por: Houben, Roland, et al.
Publicado: (2014)

Frequent loss of metastatic ability in subclones of Apc, Kras, Tgfbr2, and Trp53 mutant intestinal tumor organoids
por: Morita, Atsuya, et al.
Publicado: (2023)

A large retroperitoneal lipoblastoma as an incidental finding: a case report
por: Gerhard-Hartmann, Elena, et al.
Publicado: (2021)

Oncogenic Mutations and Gene Fusions in CD30-Positive Lymphoproliferations and Clonally Related Mycosis Fungoides Occurring in the Same Patients
por: Wobser, Marion, et al.
Publicado: (2021)

Maintenance of pluripotency in mouse ES cells without Trp53
por: Shigeta, Masaki, et al.
Publicado: (2013)

Distinct oncogenic phenotypes in hematopoietic specific deletions of Trp53
por: Palanichamy, Jayanth Kumar, et al.
Publicado: (2023)

Chemical excitation and inactivation in photoreceptors of the fly mutants trp and nss
Publicado: (1989)

Light-induced reduction in excitation efficiency in the trp mutant of Drosophila
Publicado: (1982)

Loss of TRP53 (p53) accelerates tumorigenesis and changes the tumor spectrum of SJL/J mice
por: Branca, Jane A, et al.
Publicado: (2020)

RINT1 Loss Impairs Retinogenesis Through TRP53-Mediated Apoptosis
por: Gomes, Anielle L., et al.
Publicado: (2020)

The Emergence of TRP Channels Interactome as a Potential Therapeutic Target in Pancreatic Ductal Adenocarcinoma
por: Wei, Yuanyuan, et al.
Publicado: (2023)

Combined Vhl, Trp53 and Rb1 mutation causes clear cell renal cell carcinoma in mice
por: Harlander, Sabine, et al.
Publicado: (2017)

siRNA screening identifies differences in the Fanconi anemia pathway in BALB/c-Trp53+/− with susceptibility versus C57BL/6-Trp53+/− mice with resistance to mammary tumors
por: Böhringer, M, et al.
Publicado: (2013)

The Mutant p53-Driven Secretome Has Oncogenic Functions in Pancreatic Ductal Adenocarcinoma Cells
por: Butera, Giovanna, et al.
Publicado: (2020)

Somatic Trp53 mutations differentially drive breast cancer and evolution of metastases
por: Zhang, Yun, et al.
Publicado: (2018)

Targeted Deep Sequencing of Mycosis Fungoides Reveals Intracellular Signaling Pathways Associated with Aggressiveness and Large Cell Transformation
por: Wobser, Marion, et al.
Publicado: (2021)

Panel Sequencing of Primary Cutaneous B-Cell Lymphoma
por: Wobser, Marion, et al.
Publicado: (2022)

A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage
por: Ladds, Marcus J. G. W., et al.
Publicado: (2018)

Upregulation of amplified in breast cancer 1 contributes to pancreatic ductal adenocarcinoma progression and vulnerability to blockage of hedgehog activation
por: Li, Licen, et al.
Publicado: (2021)

Chemoprevention with the metabolism modifying drugs dichloroacetate and metformin in Trp53+/- mice
por: Blackburn, AC, et al.
Publicado: (2012)

Igf2 pathway dependency of the Trp53 developmental and tumour phenotypes
por: Haley, Victoria L, et al.
Publicado: (2012)

Nucks1 synergizes with Trp53 to promote radiation lymphomagenesis in mice
por: Yue, Yangbo, et al.
Publicado: (2016)

Computational Modeling of the Thermodynamics of the Mesophilic and Thermophilic Mutants of Trp-Cage Miniprotein
por: Bò, Leonardo, et al.
Publicado: (2022)

Targeted panel sequencing in the routine diagnosis of mature T- and NK-cell lymphomas: report of 128 cases from two German reference centers
por: Böck, Julia, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_s2c5fnu1s5829lf3lmt3ic1ibg