Nuclear Receptor PXR Confers Irradiation Resistance by Promoting DNA Damage Response Through Stabilization of ATF3

Low response rate to radiotherapy remains a problem for liver and colorectal cancer patients due to inappropriate DNA damage response in tumors. Here, we report that pregnane X receptor (PXR) contributes to irradiation (IR) resistance by promoting activating transcription factor 3 (ATF3)-mediated at...

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Detalles Bibliográficos
Autores principales: Niu, Xiaxia, Cui, Hongmei, Gu, Xinsheng, Wu, Ting, Sun, Min, Zhou, Changlong, Ma, Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8965888/
https://www.ncbi.nlm.nih.gov/pubmed/35372071
http://dx.doi.org/10.3389/fonc.2022.837980

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8965888/
https://www.ncbi.nlm.nih.gov/pubmed/35372071
http://dx.doi.org/10.3389/fonc.2022.837980

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