PKPD Modeling of the Inoculum Effect of Acinetobacter baumannii on Polymyxin B in vivo

The reduction in antimicrobial activity at high bacterial counts is a microbiological phenomenon known as the inoculum effect (IE). In a previous in vitro study, a significant IE was observed for polymyxin B (PMB) against a clinical isolate of Acinetobacter baumannii, and well described by a new pha...

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Detalles Bibliográficos
Autores principales: Chauzy, Alexia, Akrong, Grace, Aranzana-Climent, Vincent, Moreau, Jérémy, Prouvensier, Laure, Mirfendereski, Hélène, Buyck, Julien M, Couet, William, Marchand, Sandrine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8966651/
https://www.ncbi.nlm.nih.gov/pubmed/35370719
http://dx.doi.org/10.3389/fphar.2022.842921

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8966651/
https://www.ncbi.nlm.nih.gov/pubmed/35370719
http://dx.doi.org/10.3389/fphar.2022.842921

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