Cargando…

Functional Investigation of a Neuronal Microcircuit in the CA1 Area of the Hippocampus Reveals Synaptic Dysfunction in Dravet Syndrome Mice

Dravet syndrome is severe childhood-onset epilepsy, caused by loss of function mutations in the SCN1A gene, encoding for the voltage-gated sodium channel Na(V)1.1. The leading hypothesis is that Dravet is caused by selective reduction in the excitability of inhibitory neurons, due to hampered activi...

Descripción completa

Detalles Bibliográficos
Autores principales: Almog, Yael, Mavashov, Anat, Brusel, Marina, Rubinstein, Moran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8966673/
https://www.ncbi.nlm.nih.gov/pubmed/35370551
http://dx.doi.org/10.3389/fnmol.2022.823640