The Enantiomer of Allopregnanolone Prevents Pressure-Mediated Retinal Degeneration Via Autophagy

In an ex vivo rat ocular hypertension (OHT) model, the neurosteroid allopregnanolone (AlloP) exerts neuroprotective effects via enhancement of both GABA(A) receptors and autophagy. We now examine whether its enantiomer (ent-AlloP), which is largely inactive at GABA receptors, offers similar neuropro...

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Detalles Bibliográficos
Autores principales: Ishikawa, Makoto, Nakazawa, Toru, Kunikata, Hiroshi, Sato, Kota, Yoshitomi, Takeshi, Krishnan, Kathiresan, Covey, Douglas F., Zorumski, Charles F., Izumi, Yukitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8966700/
https://www.ncbi.nlm.nih.gov/pubmed/35370641
http://dx.doi.org/10.3389/fphar.2022.855779

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8966700/
https://www.ncbi.nlm.nih.gov/pubmed/35370641
http://dx.doi.org/10.3389/fphar.2022.855779

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