Cargando…

The voltage-gated Ca(2+) channel subunit α(2)δ-4 regulates locomotor behavior and sensorimotor gating in mice

Voltage-gated Ca(2+) channels are critical for the development and mature function of the nervous system. Variants in the CACNA2D4 gene encoding the α(2)δ-4 auxiliary subunit of these channels are associated with neuropsychiatric and neurodevelopmental disorders. α(2)δ-4 is prominently expressed in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Klomp, Annette, Omichi, Ryotaro, Iwasa, Yoichiro, Smith, Richard J., Usachev, Yuriy M., Russo, Andrew F., Narayanan, Nandakumar S., Lee, Amy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8967030/ https://www.ncbi.nlm.nih.gov/pubmed/35353835 http://dx.doi.org/10.1371/journal.pone.0263197

Ejemplares similares

Voltage-gated calcium channel α (2)δ subunits: an assessment of proposed novel roles
por: Dolphin, Annette C.
Publicado: (2018)

Voltage‐gated calcium channels and their auxiliary subunits: physiology and pathophysiology and pharmacology
por: Dolphin, Annette C.
Publicado: (2016)

Dynamic phospholipid interaction of β2e subunit regulates the gating of voltage-gated Ca(2+) channels
por: Kim, Dong-Il, et al.
Publicado: (2015)

Trafficking and Function of the Voltage-Gated Sodium Channel β2 Subunit
por: Cortada, Eric, et al.
Publicado: (2019)

ADAM17 Mediates Proteolytic Maturation of Voltage-Gated Calcium Channel Auxiliary α(2)δ Subunits, and Enables Calcium Current Enhancement
por: Kadurin, Ivan, et al.
Publicado: (2022)

The HOOK region of voltage-gated Ca(2+) channel β subunits senses and transmits PIP(2) signals to the gate
por: Park, Cheon-Gyu, et al.
Publicado: (2017)

The β(2)-Subunit of Voltage-Gated Calcium Channels Regulates Cardiomyocyte Hypertrophy
por: Pickel, Simone, et al.
Publicado: (2021)

Strong cooperativity between subunits in voltage-gated proton channels
por: Gonzalez, Carlos, et al.
Publicado: (2009)

β subunits of voltage-gated calcium channels in cardiovascular diseases
por: Loh, Kelvin Wei Zhern, et al.
Publicado: (2023)

Gating by Cyclic Gmp and Voltage in the α Subunit of the Cyclic Gmp–Gated Channel from Rod Photoreceptors
por: Benndorf, Klaus, et al.
Publicado: (1999)

Localization of the Activation Gate of a Voltage-gated Ca(2+) Channel
por: Xie, Cheng, et al.
Publicado: (2005)

Targeting of Voltage-Gated Calcium Channel α(2)δ-1 Subunit to Lipid Rafts Is Independent from a GPI-Anchoring Motif
por: Robinson, Philip, et al.
Publicado: (2011)

Regulation of Voltage-Activated K(+) Channel Gating by Transmembrane β Subunits
por: Sun, Xiaohui, et al.
Publicado: (2012)

The Role of Auxiliary Subunits for the Functional Diversity of Voltage-Gated Calcium Channels
por: Campiglio, Marta, et al.
Publicado: (2015)

Functions of Presynaptic Voltage-gated Calcium Channels
por: Dolphin, Annette C
Publicado: (2020)

Coupling between Voltage Sensors and Activation Gate in Voltage-gated K(+) Channels
por: Lu, Zhe, et al.
Publicado: (2002)

Voltage-gated sodium channels assemble and gate as dimers
por: Clatot, Jérôme, et al.
Publicado: (2017)

Voltage-dependent gating and gating charge measurements in the Kv1.2 potassium channel
por: Ishida, Itzel G., et al.
Publicado: (2015)

Regulatory Role of Voltage-Gated Na(+) Channel β Subunits in Sensory Neurons
por: Chahine, Mohamed, et al.
Publicado: (2011)

Computational Investigation of Voltage-Gated Sodium Channel β3 Subunit Dynamics
por: Glass, William G., et al.
Publicado: (2020)

Sensorimotor gating, cannabis use and the risk of psychosis
por: Winton-Brown, T., et al.
Publicado: (2015)

Effect of Visuospatial Attention on the Sensorimotor Gating System
por: Ishii, Daisuke, et al.
Publicado: (2019)

Inactivation of Gating Currents of L-Type Calcium Channels : Specific Role of the α(2)δ Subunit
por: Shirokov, Roman, et al.
Publicado: (1998)

Histidine(168) is crucial for ΔpH-dependent gating of the human voltage-gated proton channel, hH(V)1
por: Cherny, Vladimir V., et al.
Publicado: (2018)

Lipid-dependent gating of a voltage-gated potassium channel
por: Zheng, Hui, et al.
Publicado: (2011)

Identification of BACE1 cleavage sites in human voltage-gated sodium channel beta 2 subunit
por: Gersbacher, Manuel T, et al.
Publicado: (2010)

Dysfunction of the Voltage‐Gated K(+) Channel β2 Subunit in a Familial Case of Brugada Syndrome
por: Portero, Vincent, et al.
Publicado: (2016)

Hysteresis in voltage-gated channels
por: Villalba-Galea, Carlos A.
Publicado: (2016)

Structural dynamics determine voltage and pH gating in human voltage-gated proton channel
por: Han, Shuo, et al.
Publicado: (2022)

Effect of Back-Gate Voltage on the High-Frequency Performance of Dual-Gate MoS(2) Transistors
por: Gao, Qingguo, et al.
Publicado: (2021)

Molecular insights into the gating mechanisms of voltage-gated calcium channel Ca(V)2.3
por: Gao, Yiwei, et al.
Publicado: (2023)

HIV Transgenic Rats Demonstrate Impaired Sensorimotor Gating But Are Insensitive to Cannabinoid (Δ9-Tetrahydrocannabinol)-Induced Deficits
por: Roberts, Benjamin Z, et al.
Publicado: (2021)

TMEM16A is associated with voltage-gated calcium channels in mouse retina and its function is disrupted upon mutation of the auxiliary α(2)δ(4) subunit
por: Caputo, Antonella, et al.
Publicado: (2015)

On the multiple roles of the voltage gated sodium channel β1 subunit in genetic diseases
por: Baroni, Debora, et al.
Publicado: (2015)

Nanoenviroments of the β-Subunit of L-Type Voltage-Gated Calcium Channels in Adult Cardiomyocytes
por: Cruz-Garcia, Yiliam, et al.
Publicado: (2022)

Effect of apomorphine on cognitive performance and sensorimotor gating in humans
por: Schellekens, Arnt F. A., et al.
Publicado: (2009)

Cortical grey matter volume and sensorimotor gating in schizophrenia
por: Kumari, Veena, et al.
Publicado: (2008)

Lamotrigine effects sensorimotor gating in WAG/Rij rats
por: Celikyurt, Ipek Komsuoglu, et al.
Publicado: (2012)

Caution Is Required in Interpretation of Mutations in the Voltage Sensing Domain of Voltage Gated Channels as Evidence for Gating Mechanisms
por: Kariev, Alisher M., et al.
Publicado: (2015)

Differential Expression of the β3 Subunit of Voltage-Gated Ca(2+) Channel in Mesial Temporal Lobe Epilepsy
por: Kjær, Christina, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_k36sbitl7ckhcch3960a5domik