CREBBP/EP300 acetyltransferase inhibition disrupts FOXA1-bound enhancers to inhibit the proliferation of ER+ breast cancer cells

Therapeutic targeting of the estrogen receptor (ER) is a clinically validated approach for estrogen receptor positive breast cancer (ER+ BC), but sustained response is limited by acquired resistance. Targeting the transcriptional coactivators required for estrogen receptor activity represents an alt...

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Detalles Bibliográficos
Autores principales: Bommi-Reddy, Archana, Park-Chouinard, Sungmi, Mayhew, David N., Terzo, Esteban, Hingway, Aparna, Steinbaugh, Michael J., Wilson, Jonathan E., Sims, Robert J., Conery, Andrew R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8967035/
https://www.ncbi.nlm.nih.gov/pubmed/35353838
http://dx.doi.org/10.1371/journal.pone.0262378

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8967035/
https://www.ncbi.nlm.nih.gov/pubmed/35353838
http://dx.doi.org/10.1371/journal.pone.0262378

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