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Structure of S1PR2–heterotrimeric G(13) signaling complex

Sphingosine-1-phosphate (S1P) regulates immune cell trafficking, angiogenesis, and vascular function via its five receptors. Inherited mutations in S1P receptor 2 (S1PR2) occur in individuals with hearing loss, and acquired mutations in S1PR2 and G(α13) occur in a malignant lymphoma. Here, we presen...

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Detalles Bibliográficos
Autores principales:	Chen, Hongwen, Chen, Kevin, Huang, Weijiao, Staudt, Louis M., Cyster, Jason G., Li, Xiaochun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8967229/ https://www.ncbi.nlm.nih.gov/pubmed/35353559 http://dx.doi.org/10.1126/sciadv.abn0067

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