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Structure of S1PR2–heterotrimeric G(13) signaling complex
Sphingosine-1-phosphate (S1P) regulates immune cell trafficking, angiogenesis, and vascular function via its five receptors. Inherited mutations in S1P receptor 2 (S1PR2) occur in individuals with hearing loss, and acquired mutations in S1PR2 and G(α13) occur in a malignant lymphoma. Here, we presen...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8967229/ https://www.ncbi.nlm.nih.gov/pubmed/35353559 http://dx.doi.org/10.1126/sciadv.abn0067 |