Neuronal C/EBPβ/AEP pathway shortens life span via selective GABAnergic neuronal degeneration by FOXO repression

The age-related cognitive decline of normal aging is exacerbated in neurodegenerative diseases including Alzheimer’s disease (AD). However, it remains unclear whether age-related cognitive regulators in AD pathologies contribute to life span. Here, we show that C/EBPβ, an Aβ and inflammatory cytokin...

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Detalles Bibliográficos
Autores principales: Xia, Yiyuan, Qadota, Hiroshi, Wang, Zhi-Hao, Liu, Pai, Liu, Xia, Ye, Karen X., Matheny, Courtney J., Berglund, Ken, Yu, Shan Ping, Drake, Derek, Bennett, David A., Wang, Xiao-Chuan, Yankner, Bruce A., Benian, Guy M., Ye, Keqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8967231/
https://www.ncbi.nlm.nih.gov/pubmed/35353567
http://dx.doi.org/10.1126/sciadv.abj8658

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8967231/
https://www.ncbi.nlm.nih.gov/pubmed/35353567
http://dx.doi.org/10.1126/sciadv.abj8658

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