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Plasma copeptin is increased and associated with smaller kidney volume in young adults born very preterm

BACKGROUND: Plasma copeptin, a surrogate marker for vasopressin levels, is increased in neonates born preterm, particularly in those with a more severe neonatal course, as reflected by bronchopulmonary dysplasia. Copeptin levels in adulthood are unknown. METHODS: In this case–control study of 101 ad...

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Autores principales: Flahault, Adrien, Bollée, Guillaume, El-Jalbout, Ramy, Cloutier, Anik, Santos, Robson A S, Lapeyraque, Anne-Laure, Luu, Thuy Mai, Nuyt, Anne Monique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8967663/
https://www.ncbi.nlm.nih.gov/pubmed/35371457
http://dx.doi.org/10.1093/ckj/sfab226
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author Flahault, Adrien
Bollée, Guillaume
El-Jalbout, Ramy
Cloutier, Anik
Santos, Robson A S
Lapeyraque, Anne-Laure
Luu, Thuy Mai
Nuyt, Anne Monique
author_facet Flahault, Adrien
Bollée, Guillaume
El-Jalbout, Ramy
Cloutier, Anik
Santos, Robson A S
Lapeyraque, Anne-Laure
Luu, Thuy Mai
Nuyt, Anne Monique
author_sort Flahault, Adrien
collection PubMed
description BACKGROUND: Plasma copeptin, a surrogate marker for vasopressin levels, is increased in neonates born preterm, particularly in those with a more severe neonatal course, as reflected by bronchopulmonary dysplasia. Copeptin levels in adulthood are unknown. METHODS: In this case–control study of 101 adults born very preterm (<30 weeks of gestation) and 105 control adults born full-term, a comprehensive clinical and biological assessment was performed, including blood pressure measurements, kidney ultrasound and determination of plasma copeptin, renin activity, angiotensin II, aldosterone, apelin, sodium and potassium, serum and morning urine osmolality. RESULTS: The median age in the study was 23.1 years [interquartile range (IQR) 21.2–24.8] and 57% were females. In males, the median copeptin levels were 8.2 pmol/L (IQR 6.3–12.4) and 6.1 pmol/L (IQR 4.3–9.0) in the preterm and term groups, respectively (P = 0.022). In females, the median copeptin levels were 5.2 pmol/L (IQR 3.9–7.6) and 4.0 pmol/L (IQR 2.8–5.7) in the preterm and term groups, respectively (P = 0.005). Adults born preterm with a history of bronchopulmonary dysplasia had further increased copeptin levels. The kidney volume, adjusted for height, was smaller and albuminuria was higher in the preterm group, and both were associated with higher plasma copeptin levels. CONCLUSIONS: Plasma copeptin is higher in young adults born preterm and is related to a more severe neonatal course and smaller kidney volume.
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spelling pubmed-89676632022-03-31 Plasma copeptin is increased and associated with smaller kidney volume in young adults born very preterm Flahault, Adrien Bollée, Guillaume El-Jalbout, Ramy Cloutier, Anik Santos, Robson A S Lapeyraque, Anne-Laure Luu, Thuy Mai Nuyt, Anne Monique Clin Kidney J Original Article BACKGROUND: Plasma copeptin, a surrogate marker for vasopressin levels, is increased in neonates born preterm, particularly in those with a more severe neonatal course, as reflected by bronchopulmonary dysplasia. Copeptin levels in adulthood are unknown. METHODS: In this case–control study of 101 adults born very preterm (<30 weeks of gestation) and 105 control adults born full-term, a comprehensive clinical and biological assessment was performed, including blood pressure measurements, kidney ultrasound and determination of plasma copeptin, renin activity, angiotensin II, aldosterone, apelin, sodium and potassium, serum and morning urine osmolality. RESULTS: The median age in the study was 23.1 years [interquartile range (IQR) 21.2–24.8] and 57% were females. In males, the median copeptin levels were 8.2 pmol/L (IQR 6.3–12.4) and 6.1 pmol/L (IQR 4.3–9.0) in the preterm and term groups, respectively (P = 0.022). In females, the median copeptin levels were 5.2 pmol/L (IQR 3.9–7.6) and 4.0 pmol/L (IQR 2.8–5.7) in the preterm and term groups, respectively (P = 0.005). Adults born preterm with a history of bronchopulmonary dysplasia had further increased copeptin levels. The kidney volume, adjusted for height, was smaller and albuminuria was higher in the preterm group, and both were associated with higher plasma copeptin levels. CONCLUSIONS: Plasma copeptin is higher in young adults born preterm and is related to a more severe neonatal course and smaller kidney volume. Oxford University Press 2021-11-17 /pmc/articles/PMC8967663/ /pubmed/35371457 http://dx.doi.org/10.1093/ckj/sfab226 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of the ERA. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Original Article
Flahault, Adrien
Bollée, Guillaume
El-Jalbout, Ramy
Cloutier, Anik
Santos, Robson A S
Lapeyraque, Anne-Laure
Luu, Thuy Mai
Nuyt, Anne Monique
Plasma copeptin is increased and associated with smaller kidney volume in young adults born very preterm
title Plasma copeptin is increased and associated with smaller kidney volume in young adults born very preterm
title_full Plasma copeptin is increased and associated with smaller kidney volume in young adults born very preterm
title_fullStr Plasma copeptin is increased and associated with smaller kidney volume in young adults born very preterm
title_full_unstemmed Plasma copeptin is increased and associated with smaller kidney volume in young adults born very preterm
title_short Plasma copeptin is increased and associated with smaller kidney volume in young adults born very preterm
title_sort plasma copeptin is increased and associated with smaller kidney volume in young adults born very preterm
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8967663/
https://www.ncbi.nlm.nih.gov/pubmed/35371457
http://dx.doi.org/10.1093/ckj/sfab226
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