Cargando…
Plasma copeptin is increased and associated with smaller kidney volume in young adults born very preterm
BACKGROUND: Plasma copeptin, a surrogate marker for vasopressin levels, is increased in neonates born preterm, particularly in those with a more severe neonatal course, as reflected by bronchopulmonary dysplasia. Copeptin levels in adulthood are unknown. METHODS: In this case–control study of 101 ad...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8967663/ https://www.ncbi.nlm.nih.gov/pubmed/35371457 http://dx.doi.org/10.1093/ckj/sfab226 |
_version_ | 1784678878875222016 |
---|---|
author | Flahault, Adrien Bollée, Guillaume El-Jalbout, Ramy Cloutier, Anik Santos, Robson A S Lapeyraque, Anne-Laure Luu, Thuy Mai Nuyt, Anne Monique |
author_facet | Flahault, Adrien Bollée, Guillaume El-Jalbout, Ramy Cloutier, Anik Santos, Robson A S Lapeyraque, Anne-Laure Luu, Thuy Mai Nuyt, Anne Monique |
author_sort | Flahault, Adrien |
collection | PubMed |
description | BACKGROUND: Plasma copeptin, a surrogate marker for vasopressin levels, is increased in neonates born preterm, particularly in those with a more severe neonatal course, as reflected by bronchopulmonary dysplasia. Copeptin levels in adulthood are unknown. METHODS: In this case–control study of 101 adults born very preterm (<30 weeks of gestation) and 105 control adults born full-term, a comprehensive clinical and biological assessment was performed, including blood pressure measurements, kidney ultrasound and determination of plasma copeptin, renin activity, angiotensin II, aldosterone, apelin, sodium and potassium, serum and morning urine osmolality. RESULTS: The median age in the study was 23.1 years [interquartile range (IQR) 21.2–24.8] and 57% were females. In males, the median copeptin levels were 8.2 pmol/L (IQR 6.3–12.4) and 6.1 pmol/L (IQR 4.3–9.0) in the preterm and term groups, respectively (P = 0.022). In females, the median copeptin levels were 5.2 pmol/L (IQR 3.9–7.6) and 4.0 pmol/L (IQR 2.8–5.7) in the preterm and term groups, respectively (P = 0.005). Adults born preterm with a history of bronchopulmonary dysplasia had further increased copeptin levels. The kidney volume, adjusted for height, was smaller and albuminuria was higher in the preterm group, and both were associated with higher plasma copeptin levels. CONCLUSIONS: Plasma copeptin is higher in young adults born preterm and is related to a more severe neonatal course and smaller kidney volume. |
format | Online Article Text |
id | pubmed-8967663 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-89676632022-03-31 Plasma copeptin is increased and associated with smaller kidney volume in young adults born very preterm Flahault, Adrien Bollée, Guillaume El-Jalbout, Ramy Cloutier, Anik Santos, Robson A S Lapeyraque, Anne-Laure Luu, Thuy Mai Nuyt, Anne Monique Clin Kidney J Original Article BACKGROUND: Plasma copeptin, a surrogate marker for vasopressin levels, is increased in neonates born preterm, particularly in those with a more severe neonatal course, as reflected by bronchopulmonary dysplasia. Copeptin levels in adulthood are unknown. METHODS: In this case–control study of 101 adults born very preterm (<30 weeks of gestation) and 105 control adults born full-term, a comprehensive clinical and biological assessment was performed, including blood pressure measurements, kidney ultrasound and determination of plasma copeptin, renin activity, angiotensin II, aldosterone, apelin, sodium and potassium, serum and morning urine osmolality. RESULTS: The median age in the study was 23.1 years [interquartile range (IQR) 21.2–24.8] and 57% were females. In males, the median copeptin levels were 8.2 pmol/L (IQR 6.3–12.4) and 6.1 pmol/L (IQR 4.3–9.0) in the preterm and term groups, respectively (P = 0.022). In females, the median copeptin levels were 5.2 pmol/L (IQR 3.9–7.6) and 4.0 pmol/L (IQR 2.8–5.7) in the preterm and term groups, respectively (P = 0.005). Adults born preterm with a history of bronchopulmonary dysplasia had further increased copeptin levels. The kidney volume, adjusted for height, was smaller and albuminuria was higher in the preterm group, and both were associated with higher plasma copeptin levels. CONCLUSIONS: Plasma copeptin is higher in young adults born preterm and is related to a more severe neonatal course and smaller kidney volume. Oxford University Press 2021-11-17 /pmc/articles/PMC8967663/ /pubmed/35371457 http://dx.doi.org/10.1093/ckj/sfab226 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of the ERA. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Original Article Flahault, Adrien Bollée, Guillaume El-Jalbout, Ramy Cloutier, Anik Santos, Robson A S Lapeyraque, Anne-Laure Luu, Thuy Mai Nuyt, Anne Monique Plasma copeptin is increased and associated with smaller kidney volume in young adults born very preterm |
title | Plasma copeptin is increased and associated with smaller kidney volume in young adults born very preterm |
title_full | Plasma copeptin is increased and associated with smaller kidney volume in young adults born very preterm |
title_fullStr | Plasma copeptin is increased and associated with smaller kidney volume in young adults born very preterm |
title_full_unstemmed | Plasma copeptin is increased and associated with smaller kidney volume in young adults born very preterm |
title_short | Plasma copeptin is increased and associated with smaller kidney volume in young adults born very preterm |
title_sort | plasma copeptin is increased and associated with smaller kidney volume in young adults born very preterm |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8967663/ https://www.ncbi.nlm.nih.gov/pubmed/35371457 http://dx.doi.org/10.1093/ckj/sfab226 |
work_keys_str_mv | AT flahaultadrien plasmacopeptinisincreasedandassociatedwithsmallerkidneyvolumeinyoungadultsbornverypreterm AT bolleeguillaume plasmacopeptinisincreasedandassociatedwithsmallerkidneyvolumeinyoungadultsbornverypreterm AT eljalboutramy plasmacopeptinisincreasedandassociatedwithsmallerkidneyvolumeinyoungadultsbornverypreterm AT cloutieranik plasmacopeptinisincreasedandassociatedwithsmallerkidneyvolumeinyoungadultsbornverypreterm AT santosrobsonas plasmacopeptinisincreasedandassociatedwithsmallerkidneyvolumeinyoungadultsbornverypreterm AT lapeyraqueannelaure plasmacopeptinisincreasedandassociatedwithsmallerkidneyvolumeinyoungadultsbornverypreterm AT luuthuymai plasmacopeptinisincreasedandassociatedwithsmallerkidneyvolumeinyoungadultsbornverypreterm AT nuytannemonique plasmacopeptinisincreasedandassociatedwithsmallerkidneyvolumeinyoungadultsbornverypreterm |