ACE2 binding is an ancestral and evolvable trait of sarbecoviruses

Two different sarbecoviruses have caused major human outbreaks in the past two decades(1,2). Both of these sarbecoviruses, SARS-CoV-1 and SARS-CoV-2, engage ACE2 through the spike receptor-binding domain(2–6). However, binding to ACE2 orthologues of humans, bats and other species has been observed o...

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Detalles Bibliográficos
Autores principales: Starr, Tyler N., Zepeda, Samantha K., Walls, Alexandra C., Greaney, Allison J., Alkhovsky, Sergey, Veesler, David, Bloom, Jesse D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8967715/
https://www.ncbi.nlm.nih.gov/pubmed/35114688
http://dx.doi.org/10.1038/s41586-022-04464-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8967715/
https://www.ncbi.nlm.nih.gov/pubmed/35114688
http://dx.doi.org/10.1038/s41586-022-04464-z

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