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ACE2 binding is an ancestral and evolvable trait of sarbecoviruses
Two different sarbecoviruses have caused major human outbreaks in the past two decades(1,2). Both of these sarbecoviruses, SARS-CoV-1 and SARS-CoV-2, engage ACE2 through the spike receptor-binding domain(2–6). However, binding to ACE2 orthologues of humans, bats and other species has been observed o...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8967715/ https://www.ncbi.nlm.nih.gov/pubmed/35114688 http://dx.doi.org/10.1038/s41586-022-04464-z |