Apoptolidin family glycomacrolides target leukemia through inhibition of ATP synthase

Cancer cells have long been recognized to exhibit unique bioenergetic requirements. The apoptolidin family of glycomacrolides are distinguished by their selective cytotoxicity towards oncogene transformed cells, yet their molecular mechanism remains uncertain. We used photoaffinity analogs of the ap...

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Detalles Bibliográficos
Autores principales: Reisman, Benjamin J., Guo, Hui, Ramsey, Haley E., Wright, Madison T., Reinfeld, Bradley I., Ferrell, P. Brent, Sulikowski, Gary A., Rathmell, W. Kimryn, Savona, Michael R., Plate, Lars, Rubinstein, John L., Bachmann, Brian O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8967781/
https://www.ncbi.nlm.nih.gov/pubmed/34857958
http://dx.doi.org/10.1038/s41589-021-00900-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8967781/
https://www.ncbi.nlm.nih.gov/pubmed/34857958
http://dx.doi.org/10.1038/s41589-021-00900-9

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