ESCRT-I fuels lysosomal degradation to restrict TFEB/TFE3 signaling via the Rag-mTORC1 pathway

Within the endolysosomal pathway in mammalian cells, ESCRT complexes facilitate degradation of proteins residing in endosomal membranes. Here, we show that mammalian ESCRT-I restricts the size of lysosomes and promotes degradation of proteins from lysosomal membranes, including MCOLN1, a Ca(2+) chan...

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Detalles Bibliográficos
Autores principales: Wróbel, Marta, Cendrowski, Jarosław, Szymańska, Ewelina, Grębowicz-Maciukiewicz, Malwina, Budick-Harmelin, Noga, Macias, Matylda, Szybińska, Aleksandra, Mazur, Michał, Kolmus, Krzysztof, Goryca, Krzysztof, Dąbrowska, Michalina, Paziewska, Agnieszka, Mikula, Michał, Miączyńska, Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8967991/
https://www.ncbi.nlm.nih.gov/pubmed/35354596
http://dx.doi.org/10.26508/lsa.202101239

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8967991/
https://www.ncbi.nlm.nih.gov/pubmed/35354596
http://dx.doi.org/10.26508/lsa.202101239

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