Displacement of Native FXYD Protein From Na(+)/K(+)-ATPase With Novel FXYD Peptide Derivatives: Effects on Doxorubicin Cytotoxicity

The seven mammalian FXYD proteins associate closely with α/β heterodimers of Na(+)/K(+)-ATPase. Most of them protect the β1 subunit against glutathionylation, an oxidative modification that destabilizes the heterodimer and inhibits Na(+)/K(+)-ATPase activity. A specific cysteine (Cys) residue of FXY...

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Detalles Bibliográficos
Autores principales: Liu, Chia-Chi, Kim, Yeon Jae, Teh, Rachel, Garcia, Alvaro, Hamilton, Elisha J., Cornelius, Flemming, Baxter, Robert C., Rasmussen, Helge H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8968713/
https://www.ncbi.nlm.nih.gov/pubmed/35371992
http://dx.doi.org/10.3389/fonc.2022.859216

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8968713/
https://www.ncbi.nlm.nih.gov/pubmed/35371992
http://dx.doi.org/10.3389/fonc.2022.859216

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