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Inflammation and Brain Structure in Schizophrenia and Other Neuropsychiatric Disorders: A Mendelian Randomization Study

IMPORTANCE: Previous in vitro and postmortem research suggests that inflammation may lead to structural brain changes via activation of microglia and/or astrocytic dysfunction in a range of neuropsychiatric disorders. OBJECTIVE: To investigate the relationship between inflammation and changes in bra...

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Detalles Bibliográficos
Autores principales: Williams, John A., Burgess, Stephen, Suckling, John, Lalousis, Paris Alexandros, Batool, Fatima, Griffiths, Sian Lowri, Palmer, Edward, Karwath, Andreas, Barsky, Andrey, Gkoutos, Georgios V., Wood, Stephen, Barnes, Nicholas M., David, Anthony S., Donohoe, Gary, Neill, Joanna C., Deakin, Bill, Khandaker, Golam M., Upthegrove, Rachel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Medical Association 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8968718/
https://www.ncbi.nlm.nih.gov/pubmed/35353173
http://dx.doi.org/10.1001/jamapsychiatry.2022.0407