Interleukin 4 promotes phagocytosis of murine leukemia cells counteracted by CD47 upregulation

Cytokines are key regulators of tumor immune surveillance by controlling immune cell activity. Here, we investigated whether interleukin 4 (IL4) has antileukemic activity via immune-mediated mechanisms in an in vivo murine model of acute myeloid leukemia driven by the MLL–AF9 fusion gene. Although I...

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Detalles Bibliográficos
Autores principales: Peña-Martínez, Pablo, Ramakrishnan, Ramprasad, Högberg, Carl, Jansson, Caroline, Nord, David Gisselsson, Järås, Marcus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8968882/
https://www.ncbi.nlm.nih.gov/pubmed/33951888
http://dx.doi.org/10.3324/haematol.2020.270421

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8968882/
https://www.ncbi.nlm.nih.gov/pubmed/33951888
http://dx.doi.org/10.3324/haematol.2020.270421

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