Metabolism of a Selective Serotonin and Norepinephrine Reuptake Inhibitor Duloxetine in Liver Microsomes and Mice

Duloxetine (DLX) is a dual serotonin and norepinephrine reuptake inhibitor, widely used for the treatment of major depressive disorder. Although DLX has shown good efficacy and safety, serious adverse effects (e.g., liver injury) have been reported. The mechanisms associated with DLX-induced toxicit...

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Detalles Bibliográficos
Autores principales: Qin, Xuan, Hakenjos, John M., MacKenzie, Kevin R., Barzi, Mercedes, Chavan, Hemantkumar, Nyshadham, Pranavanand, Wang, Jin, Jung, Sung Yun, Guner, Joie Z., Chen, Si, Guo, Lei, Krishnamurthy, Partha, Bissig, Karl-Dimiter, Palmer, Stephen, Matzuk, Martin M., Li, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8969139/
https://www.ncbi.nlm.nih.gov/pubmed/34785568
http://dx.doi.org/10.1124/dmd.121.000633

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8969139/
https://www.ncbi.nlm.nih.gov/pubmed/34785568
http://dx.doi.org/10.1124/dmd.121.000633

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