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Metabolism of a Selective Serotonin and Norepinephrine Reuptake Inhibitor Duloxetine in Liver Microsomes and Mice
Duloxetine (DLX) is a dual serotonin and norepinephrine reuptake inhibitor, widely used for the treatment of major depressive disorder. Although DLX has shown good efficacy and safety, serious adverse effects (e.g., liver injury) have been reported. The mechanisms associated with DLX-induced toxicit...
Autores principales: | Qin, Xuan, Hakenjos, John M., MacKenzie, Kevin R., Barzi, Mercedes, Chavan, Hemantkumar, Nyshadham, Pranavanand, Wang, Jin, Jung, Sung Yun, Guner, Joie Z., Chen, Si, Guo, Lei, Krishnamurthy, Partha, Bissig, Karl-Dimiter, Palmer, Stephen, Matzuk, Martin M., Li, Feng |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society for Pharmacology and Experimental Therapeutics
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8969139/ https://www.ncbi.nlm.nih.gov/pubmed/34785568 http://dx.doi.org/10.1124/dmd.121.000633 |
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