SMO Regulates IGF1R levels and AKT Localization and Signaling

The oncoprotein Smoothened (SMO), a Frizzled-class-G-protein-coupled receptor, is the central transducer of Hedgehog (Hh) signaling. While canonical SMO signaling is best understood in the context of cilia, evidence suggests that SMO has other functions in cancer biology that are unrelated to canoni...

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Detalles Bibliográficos
Autores principales: Agarwal, Nitin K, Kim, Chae-Hwa, Kunkalla, Kranthi, Vaghefi, Amineh, Sanchez, Sandra, Manuel, Samantha, Bilbao, Daniel, Vega, Francisco, Landgraf, Ralf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8969180/
https://www.ncbi.nlm.nih.gov/pubmed/34893758
http://dx.doi.org/10.1038/s41374-021-00702-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8969180/
https://www.ncbi.nlm.nih.gov/pubmed/34893758
http://dx.doi.org/10.1038/s41374-021-00702-6

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