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Haemin deprivation renders Bacteroides fragilis hypersusceptible to metronidazole and cancels high-level metronidazole resistance

BACKGROUND: Infections with Bacteroides fragilis are routinely treated with metronidazole, a 5-nitroimidazole antibiotic that is active against most anaerobic microorganisms. Metronidazole has remained a reliable treatment option, but resistance does occur, including in B. fragilis. OBJECTIVES: In t...

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Detalles Bibliográficos
Autores principales: Paunkov, Ana, Gutenbrunner, Katrin, Sóki, József, Leitsch, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8969417/
https://www.ncbi.nlm.nih.gov/pubmed/35040989
http://dx.doi.org/10.1093/jac/dkab485