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A Single Amino Acid Substitution in Structural Protein VP2 Abrogates the Neurotropism of Enterovirus A-71 in Mice
Enterovirus 71 (EV-A71) causes hand, foot, and mouth disease (HFMD) in children and has been associated with neurological complications. With no specific treatment and a monovalent vaccine limited to the Chinese market, HFMD remains a serious public health concern and an economic burden to affected...
Autores principales: | Yeo, Huimin, Chong, Connie Wan Hui, Chen, Elijah Weihua, Lim, Ze Qin, Ng, Qing Yong, Yan, Benedict, Chu, Justin Jang Hann, Chow, Vincent T. K., Alonso, Sylvie |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8969769/ https://www.ncbi.nlm.nih.gov/pubmed/35369482 http://dx.doi.org/10.3389/fmicb.2022.821976 |
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