Heteroplasmy of Wild-Type Mitochondrial DNA Variants in Mice Causes Metabolic Heart Disease With Pulmonary Hypertension and Frailty

In most eukaryotic cells, the mitochondrial DNA (mtDNA) is transmitted uniparentally and present in multiple copies derived from the clonal expansion of maternally inherited mtDNA. All copies are therefore near-identical, or homoplasmic. The presence of >1 mtDNA variant in the same cytoplasm can...

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Detalles Bibliográficos
Autores principales: Lechuga-Vieco, Ana Victoria, Latorre-Pellicer, Ana, Calvo, Enrique, Torroja, Carlos, Pellico, Juan, Acín-Pérez, Rebeca, García-Gil, María Luisa, Santos, Arnoldo, Bagwan, Navratan, Bonzon-Kulichenko, Elena, Magni, Ricardo, Benito, Marina, Justo-Méndez, Raquel, Simon, Anna Katharina, Sánchez-Cabo, Fátima, Vázquez, Jesús, Ruíz-Cabello, Jesús, Enríquez, José Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Original Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8969846/
https://www.ncbi.nlm.nih.gov/pubmed/35236094
http://dx.doi.org/10.1161/CIRCULATIONAHA.121.056286

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8969846/
https://www.ncbi.nlm.nih.gov/pubmed/35236094
http://dx.doi.org/10.1161/CIRCULATIONAHA.121.056286

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