Exploring a peptide nucleic acid-based antisense approach for CD5 targeting in chronic lymphocytic leukemia

We herein report an innovative antisense approach based on Peptide Nucleic Acids (PNAs) to down-modulate CD5 expression levels in chronic lymphocytic leukemia (CLL). Using bioinformatics tools, we selected a 12-mer tract of the CD5 mRNA as the molecular target and synthesized the complementary and c...

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Detalles Bibliográficos
Autores principales: Cesaro, Elena, Falanga, Andrea Patrizia, Catapano, Rosa, Greco, Francesca, Romano, Simona, Borbone, Nicola, Pastore, Arianna, Marzano, Maria, Chiurazzi, Federico, D’Errico, Stefano, Piccialli, Gennaro, Oliviero, Giorgia, Costanzo, Paola, Grosso, Michela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8970396/
https://www.ncbi.nlm.nih.gov/pubmed/35358273
http://dx.doi.org/10.1371/journal.pone.0266090

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8970396/
https://www.ncbi.nlm.nih.gov/pubmed/35358273
http://dx.doi.org/10.1371/journal.pone.0266090

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