GFPT2/GFAT2 and AMDHD2 act in tandem to control the hexosamine pathway

The hexosamine biosynthetic pathway (HBP) produces the essential metabolite UDP-GlcNAc and plays a key role in metabolism, health, and aging. The HBP is controlled by its rate-limiting enzyme glutamine fructose-6-phosphate amidotransferase (GFPT/GFAT) that is directly inhibited by UDP-GlcNAc in a fe...

Descripción completa

Detalles Bibliográficos
Autores principales: Kroef, Virginia, Ruegenberg, Sabine, Horn, Moritz, Allmeroth, Kira, Ebert, Lena, Bozkus, Seyma, Miethe, Stephan, Elling, Ulrich, Schermer, Bernhard, Baumann, Ulrich, Denzel, Martin Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8970586/
https://www.ncbi.nlm.nih.gov/pubmed/35229715
http://dx.doi.org/10.7554/eLife.69223

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8970586/
https://www.ncbi.nlm.nih.gov/pubmed/35229715
http://dx.doi.org/10.7554/eLife.69223

Ejemplares similares