Direct cellular reprogramming enables development of viral T antigen–driven Merkel cell carcinoma in mice

Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin cancer that frequently carries an integrated Merkel cell polyomavirus (MCPyV) genome and expresses viral transforming antigens (TAgs). MCC tumor cells also express signature genes detected in skin-resident, postmitotic Merkel cells, in...

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Detalles Bibliográficos
Autores principales: Verhaegen, Monique E., Harms, Paul W., Van Goor, Julia J., Arche, Jacob, Patrick, Matthew T., Wilbert, Dawn, Zabawa, Haley, Grachtchouk, Marina, Liu, Chia-Jen, Hu, Kevin, Kelly, Michael C., Chen, Ping, Saunders, Thomas L., Weidinger, Stephan, Syu, Li-Jyun, Runge, John S., Gudjonsson, Johann E., Wong, Sunny Y., Brownell, Isaac, Cieslik, Marcin, Udager, Aaron M., Chinnaiyan, Arul M., Tsoi, Lam C., Dlugosz, Andrzej A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Concise Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8970662/
https://www.ncbi.nlm.nih.gov/pubmed/35143422
http://dx.doi.org/10.1172/JCI152069

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8970662/
https://www.ncbi.nlm.nih.gov/pubmed/35143422
http://dx.doi.org/10.1172/JCI152069

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