Cargando…

An acid trip activates protumoral macrophages to promote hepatocellular carcinoma malignancy

Tumor-associated macrophages (TAMs) promote metastasis and tumor cell extravasation, survival, and growth. In hepatocellular carcinoma (HCC), the presence of TAM subpopulations correlates with poor outcome. In this issue of the JCI, Ning et al. report on their use of cell culture, mouse models, and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Graham, Nicola, Pollard, Jeffrey W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2022
Materias:	Commentary
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8970664/ https://www.ncbi.nlm.nih.gov/pubmed/35362482 http://dx.doi.org/10.1172/JCI158562

Ejemplares similares

Potential therapeutic targets in the tumor microenvironment of hepatocellular carcinoma: reversing the protumor effect of tumor-associated macrophages
por: Zhou, Jingyi, et al.
Publicado: (2021)

Tumor-Associated Macrophages: Protumoral Macrophages in Inflammatory Tumor Microenvironment
por: Malekghasemi, Somaiyeh, et al.
Publicado: (2020)

Involvement of protumor macrophages in breast cancer progression and characterization of macrophage phenotypes
por: Komohara, Yoshihiro, et al.
Publicado: (2023)

Cancer-associated fibroblasts promote an immunosuppressive microenvironment through the induction and accumulation of protumoral macrophages
por: Takahashi, Hideyuki, et al.
Publicado: (2016)

Enhanced lipid biosynthesis in human tumor-induced macrophages contributes to their protumoral characteristics
por: Rabold, Katrin, et al.
Publicado: (2020)

Protumoral roles of melanoma inhibitory activity 2 in oral squamous cell carcinoma
por: Kurihara, M, et al.
Publicado: (2013)

Extracellular vesicles shed from gastric cancer mediate protumor macrophage differentiation
por: Ito, Atene, et al.
Publicado: (2021)

N‐acetylaspartate release by glutaminolytic ovarian cancer cells sustains protumoral macrophages
por: Menga, Alessio, et al.
Publicado: (2021)

A Trip to Egypt: De-Nile
por: Alpert, Joseph S.
Publicado: (2022)

Melanoma-specific bcl-2 promotes a protumoral M2-like phenotype by tumor-associated macrophages
por: Di Martile, Marta, et al.
Publicado: (2020)

Protumor immunity and breast cancer development
por: Coussens, LM
Publicado: (2009)

Nanotherapy delivery of c-myc inhibitor targets Protumor Macrophages and preserves Antitumor Macrophages in Breast Cancer
por: Esser, Alison K., et al.
Publicado: (2020)

XBP1 regulates the protumoral function of tumor-associated macrophages in human colorectal cancer
por: Zhao, Yahui, et al.
Publicado: (2021)

S100A4 enhances protumor macrophage polarization by control of PPAR-γ-dependent induction of fatty acid oxidation
por: Liu, Shuangqing, et al.
Publicado: (2021)

Claudin-Low Breast Cancer Inflammatory Signatures Support Polarization of M1-Like Macrophages with Protumoral Activity
por: Suárez-Arriaga, Mayra Cecilia, et al.
Publicado: (2021)

Augmented trabeculectomy – The surgical journey and road trip forward
por: Ramesh, Prasanna V, et al.
Publicado: (2023)

High mammographic density in women is associated with protumor inflammation
por: Huo, Cecilia W., et al.
Publicado: (2018)

P044: PIM kinases support protumoral and immunosuppressive phenotype and functions of macrophages in classical Hodgkin Lymphoma
por: Szydłowski, Maciej, et al.
Publicado: (2022)

The Significance of SPP1 in Lung Cancers and Its Impact as a Marker for Protumor Tumor-Associated Macrophages
por: Matsubara, Eri, et al.
Publicado: (2023)

Regulation and Functions of Protumoral Unconventional T Cells in Solid Tumors
por: Barsac, Emilie, et al.
Publicado: (2021)

Basal Cell Carcinoma in Gorlin’s Patients: a Matter of Fibroblasts-Led Protumoral Microenvironment?
por: Gache, Yannick, et al.
Publicado: (2015)

The round trip model for severe herpes zoster caused by live attenuated varicella vaccine virus
por: Grose, Charles, et al.
Publicado: (2020)

Protumor Activities of the Immune Response: Insights in the Mechanisms of Immunological Shift, Oncotraining, and Oncopromotion
por: Chimal-Ramírez, G. K., et al.
Publicado: (2013)

Estrogen reprograms the activity of neutrophils to foster protumoral microenvironment during mammary involution
por: Chung, Hwa Hwa, et al.
Publicado: (2017)

TRIM55 Promotes Proliferation of Hepatocellular Carcinoma Through Stabilizing TRIP6 to Activate Wnt/β-Catenin Signaling
por: Lu, Xun, et al.
Publicado: (2023)

Coagulation factor VII and malignant progression of hepatocellular carcinoma
por: Chen, K-D, et al.
Publicado: (2016)

CSF1R Inhibition Combined with GM-CSF Reprograms Macrophages and Disrupts Protumoral Interplays with AML Cells
por: Smirnova, Tatiana, et al.
Publicado: (2021)

TGF-β Mediated Crosstalk Between Malignant Hepatocyte and Tumor Microenvironment in Hepatocellular Carcinoma
por: Gupta, Devendra Kumar, et al.
Publicado: (2014)

Genomic Instability and Protumoral Inflammation Are Associated with Primary Resistance to Anti–PD-1 + Antiangiogenesis in Malignant Pleural Mesothelioma
por: Danlos, François-Xavier, et al.
Publicado: (2023)

Acidic extracellular pH drives accumulation of N1-acetylspermidine and recruitment of protumor neutrophils
por: Kato, Miki, et al.
Publicado: (2023)

Myeloid ERK5 deficiency suppresses tumor growth by blocking protumor macrophage polarization via STAT3 inhibition
por: Giurisato, Emanuele, et al.
Publicado: (2018)

Trip and Trip Pro
por: Fox, Lynne M.
Publicado: (2018)

Ethical decision-making in biopharmaceutical research and development: applying values using the TRIP & TIPP model
por: Poplazarova, Tatjana, et al.
Publicado: (2020)

Recently published papers: Clunk-click every trip, smile, but don't stop for a drink on the way
por: Stacey, Jon, et al.
Publicado: (2004)

Clinical and transcriptional signatures of human CD204 reveal an applicable marker for the protumor phenotype of tumor-associated macrophages in breast cancer
por: He, Yunjie, et al.
Publicado: (2019)

Monocyte Differentiation towards Protumor Activity Does Not Correlate with M1 or M2 Phenotypes
por: Chimal-Ramírez, G. Karina, et al.
Publicado: (2016)

Current understanding of cancer-intrinsic PD-L1: regulation of expression and its protumoral activity
por: Yadollahi, Pedram, et al.
Publicado: (2021)

Protumoral TSP50 Regulates Macrophage Activities and Polarization via Production of TNF-α and IL-1β, and Activation of the NF-κB Signaling Pathway
por: Yang, Cheng, et al.
Publicado: (2015)

Upregulation of TRIP13 promotes the malignant progression of lung cancer via the EMT pathway
por: Lu, Rujian, et al.
Publicado: (2021)

TRIP13 overexpression in hepatocellular carcinoma: implications for poor prognosis and immune cell infiltration
por: Xue, Jiapeng, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_8q5qr5q9epcsvj2ubpdiaunn5p